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Journal / Immunology and Infection / P. 阿鲁吉诺萨…
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Immunology and Infection

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JoVE Journal Immunology and Infection
P. 阿鲁吉诺萨 气液界面中支气皮细胞和巨噬细胞的感染三维共培养，用于抗感染的临床前评估
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Journal (Immunology and Infection)
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Detection of Bacteria Using Fluorogenic DNAzymes
Journal (Immunology and Infection)
Detection of Bacteria Using Fluorogenic DNAzymes
 
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P. 阿鲁吉诺萨 气液界面中支气皮细胞和巨噬细胞的感染三维共培养，用于抗感染的临床前评估

Article DOI: 10.3791/61069-v • 10:26 min • June 15th, 2020
June 15th, 2020 •
*1,2, *1,2, 3, 4, 4, 3, 1, 1, 1,2
1Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 2Department of Pharmacy, Saarland University, 3Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 4Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital
* These authors contributed equally

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我们描述了一个协议，一个三维共培养模型的感染气道，使用CFBE41o- 细胞，THP-1 巨噬细胞，和伪多莫纳斯aeruginosa，建立在空气-液体接口。该模型提供了一个新的平台，同时测试抗生素疗效，上皮屏障功能和炎症标记。

Tags

本月在 Jove， 问题 160， 生物膜， 抗生素， 肺部感染， 囊性纤维化， 炎症， 间体， TEER， 动物试验的替代品
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