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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
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JoVE Journal Medicine
Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

DOI:
10.3791/3308-v

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07:51 min

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January 13, 2012

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, , , , , , , ,
1European Institute for Molecular Imaging,Westfälische Wilhelms-University Münster, 2British Heart Foundation Cardiovascular Sciences Unit,Imperial College London , 3Department of Bioengineering,Imperial College London , 4Biomedical Engineering,Eindhoven University of Technology

Chapters

  • 00:05Title
  • 01:09Preparing the Shear Stress Modifier
  • 01:59Implanting the Cuff Around the Right Carotid Artery
  • 06:35Results: Shear Stress
  • 07:33Conclusion

Summary

Automatic Translation

Automatic Translation

The constricting cuff presented in this article is designed to induce atherosclerosis in the murine common carotid artery. Due to the conical shape of its inner lumen the implanted cuff generates well-defined regions of low, high and oscillatory shear stress triggering the development of atherosclerotic lesions of different inflammatory phenotypes.

Tags

Carotid CuffShear StressAtherosclerosisInflammatory GenesEndothelial CellsFlow DynamicsSmall Animal ModelsPlaque DevelopmentCarotid Artery LigationEndothelial DysfunctionAtherosclerotic LesionsShear Stress Modifying CuffFluid DynamicsDefined Regions Of Shear StressCommon Carotid ArteryApolipoprotein E (ApoE) Knockout MiceHigh Cholesterol Diet

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