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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
 

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Article doi: 10.3791/3308
January 13th, 2012

Summary January 13th, 2012

The constricting cuff presented in this article is designed to induce atherosclerosis in the murine common carotid artery. Due to the conical shape of its inner lumen the implanted cuff generates well-defined regions of low, high and oscillatory shear stress triggering the development of atherosclerotic lesions of different inflammatory phenotypes.

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