Hindlimb Grasp Reflex

The hindlimb grasp reflex is an involuntary behavioral response in which an animal flexes its toes or hind paw after stimulation of the limb, providing a measurable indicator of sensorimotor function. Sensory receptors in the skin and deeper tissues detect contact, and neural circuits in the spinal cord coordinate muscle activation that closes the digits around a surface or stimulus. Researchers use this reflex in behavioral neuroscience to assess motor development, tactile processing, spinal cord circuitry, and changes caused by injury, disease, or experimental treatment. Its strength, timing, and persistence can reveal alterations in nervous system function.

Hindlimb Grasp Reflex - Related Videos

Research

JoVE Journal - Behavior

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

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Cited by 74 •

2017

Behavioral testing is the gold standard for determining outcomes following brain injury, and can identify the presence of developmental disabilities in infants and children. Neurodevelopmental reflexes are an early indicator of these abnormalities. A host of easily accomplished developmental reflex tests in the neonatal rodent were developed and described here.

Methods for Acute and Subacute Murine Hindlimb Ischemia

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Cited by 29 •

2016

Surgical induction of hindlimb ischemia in the mouse is useful to examine angiogenesis, however this is compromised in certain inbred mouse strains that display marked ischemia-induced tissue necrosis. Methods are described to induce subacute limb ischemia using ameroid constrictors to circumvent this problem through the induction of gradual arterial occlusion.

Hindlimb Skeletal Muscle Extraction: A Procedure to Excise Hindlimb Skeletal Muscles from Murine Model

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2023

In this video, we describe the procedure to excise hindlimb skeletal muscles from a mouse model. The excised muscles can be stored at lower temperatures until further downstream...

Education

JoVE Core - Anatomy and Physiology

Reflex Activity

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2024

A reflex activity is an automatic, involuntary response to specific stimuli. It is a part of our survival mechanism, designed to protect us from potential harm. For example, when a bright light suddenly shines into our eyes, we instinctively close them or look away. This is a simple reflex activity orchestrated by the nervous system without conscious thought or effort. A reflex exam is a diagnostic procedure performed by a healthcare professional to evaluate the functionality of a patient's...

The Micturition Reflex

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2024

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying. The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...

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