Cij Mixer
Cij Mixer - Related Videos
12:42
Microfluidic Mixers for Studying Protein Folding
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Cited by 9 •
2012
In this work we explain the fabrication and use of a microfluidic mixer capable of mixing two solutions in ~8 μs. We also demonstrate the use of these mixers with spectroscopic detection using UV fluorescence and fluorescence resonance energy transfer (FRET).
08:10
Synthesizing Lipid Nanoparticles by Turbulent Flow in Confined Impinging Jet Mixers
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Cited by 20 •
2024
A detailed protocol for synthesizing lipid nanoparticles (LNPs) using confined impinging jet (CIJ) mixer technologies, including a two-jet CIJ and a four-jet multi-inlet vortex mixer (µMIVM), is demonstrated. The CIJ mixers generate reproducible, turbulent micro-mixing environments, resulting in the production of monodisperse LNPs.
10:38
Measurement of the Rheology of Crude Oil in Equilibrium with CO2 at Reservoir Conditions
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Cited by 2 •
2017
A method for measuring the rheology of crude oil in equilibrium with carbon dioxide at reservoir conditions is presented.
07:33
Quantifying Mixing using Magnetic Resonance Imaging
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Cited by 5 •
2012
Magnetic resonance imaging (MRI) provides a powerful tool to evaluate the effectiveness of process equipment during operation. We discuss the use of MRI to visualize mixing in a static mixer. The application is relevant to personal care products, but can be applied to a broad range of food, chemical, biomass and biological fluids.
04:52
Increasing cDNA Yields from Single-cell Quantities of mRNA in Standard Laboratory Reverse Transcriptase Reactions using Acoustic Microstreaming
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Cited by 11 •
2011
We describe a novel method for increasing cDNA yield from single-cell quantities of mRNA in otherwise standard laboratory reverse transcription reactions. The novelty resides in the use of a micromixer, which utilizes the phenomenon of acoustic microstreaming, to mix fluids at microliter scales more effectively than shaking, vortexing or trituration.
FAQs
Opposing liquid jets collide within the confined chamber, creating intense turbulence and rapidly dissipating energy. This action breaks down concentration differences between the incoming streams more quickly than relying on simple bulk circulation. The resulting reduction in concentration gradients supports more uniform formulations and helps establish controlled conditions for particle formation.
Turbulence promotes rapid redistribution of the incoming fluids, while energy dissipation converts the jets’ directed motion into small-scale mixing within the chamber. Together, these effects shorten the time required for homogenization and limit localized differences in composition. That control is especially relevant when formulation conditions influence the formation of delivery-system particles.
The confined chamber provides a defined space where the opposing streams meet and their interaction is concentrated. Rather than allowing the fluids to mix gradually across an open volume, the design focuses impingement and turbulence at the collision region. This configuration supports reproducible mixing conditions for formulation studies and controlled processing.
By bringing formulation streams together under a controlled impingement configuration, the mixer reduces concentration gradients during the early stages of processing. More consistent mixing can help researchers examine how formulation conditions affect lipid nanoparticles, polymeric particles, liposomes, and related systems. Reproducibility also makes the device useful for comparing formulations and optimizing particle preparation.
Formulation streams are directed through opposing inlets into the confined mixing chamber, where they collide and rapidly homogenize. The mixed output can then be used as the prepared formulation or as material for subsequent particle-formation studies. In practice, the workflow centers on controlled stream delivery, confined impingement, and evaluation of the resulting formulation.
In bioengineering, these mixers support preparation of lipid nanoparticles, polymeric particles, liposomes, and other drug-delivery systems. Their rapid and controlled mixing is relevant when researchers need to investigate formulation behavior, particle formation, or mass transfer. The same capabilities connect small-scale formulation studies with broader efforts in biomedical processing and continuous manufacturing.
A scalable design allows the same underlying mixing approach to contribute beyond individual formulation experiments. Researchers can use CIJ mixer systems to study mass transfer, optimize formulations, and investigate continuous manufacturing for biomedical applications. This makes the device relevant both for controlled laboratory studies and for developing processing strategies intended to extend across production scales.
These studies can reveal how controlled mixing conditions relate to homogenization, concentration-gradient reduction, and particle formation. Researchers can apply the system to formulation optimization and mass-transfer investigations while examining lipid nanoparticles, polymeric particles, liposomes, or other delivery systems. The resulting comparisons help connect mixing behavior with the performance of biomedical formulation processes.