High Intensity Focused Ultrasound
High Intensity Focused Ultrasound - Related Videos
07:38
Real-time Monitoring of High Intensity Focused Ultrasound (HIFU) Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound (HMIFU)
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Cited by 13 •
2015
This article describes real-time monitoring of HIFU ablation in canine liver with high frame rate ultrasound imaging using diverging and plane wave imaging. Harmonic Motion Imaging for Focused Ultrasound is used to image the decrease of acoustic radiation force induced displacement in the ablated region.
07:04
High-Intensity Focused Ultrasound for Blocking Nerve Action Potentials in a Diabetic Rat Model
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2025
Source: Lee, Y. F., et al. An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models. J. Vis. Exp. (2017)This video demonstrates the use of high-intensity focused ultrasound (HIFU) to block action potentials from the sciatic nerve to the gastrocnemius muscle in a diabetic rat model. Upon delivering the HIFU beam to the nerve, a decrease in muscle signal confirms HIFU's potential as a non-invasive therapy for diabetic neuropathic pain relief.
08:08
Evaluating Targeting Accuracy in the Focal Plane for an Ultrasound-guided High-intensity Focused Ultrasound Phased-array System
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2019
This study describes a protocol to evaluate the targeting accuracy in the focal plane of an ultrasound-guided high-intensity focused ultrasound phased-array system.
08:51
Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound
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Cited by 13 •
2012
This protocol describes the stimulation of cultured fibroblasts with low-intensity pulsed ultrasound, which drives focal adhesion formation and Rac1 activation by mimicking engagement of the transmembrane matrix receptor, syndecan-4. This approach allows investigation of a successful clinical technique at the cellular level, thereby providing opportunities for refinement of the therapy.
09:03
Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
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Cited by 7 •
2023
Disruption of the blood-spinal cord barrier (BSCB) can be successfully achieved with the intravenous administration of microbubbles and the application of low-intensity focused ultrasound (LIFU). This protocol details the opening of the BSCB using LIFU in a rodent model, including equipment setup, microbubble injection, target localization, and BSCB disruption visualization.
FAQs
An array of ultrasound transducers adjusts the phase and alignment of individual acoustic waves so they converge at a selected location. This coordinated timing concentrates energy at the target rather than distributing it uniformly through the surrounding region. In bioengineering, controlling convergence is central to designing devices that deliver remote, localized effects with greater targeting precision.
The concentrated acoustic field can produce localized heating, mechanical stress, or cavitation. These effects provide different ways to alter tissue or other materials, depending on how the ultrasound energy interacts with the target. Selecting and controlling the relevant effect helps bioengineers match the treatment mechanism to goals such as ablation, delivery, stimulation, or material modification.
Treatment outcomes depend on the combined influence of acoustic power, exposure time, tissue properties, and targeting accuracy. Changes in these factors can alter the magnitude or location of the resulting tissue effect, including heating, mechanical stress, or cavitation. Considering them together is essential when developing therapeutic devices or tissue models intended to produce reproducible localized responses.
Targeting accuracy determines whether the concentrated acoustic effect reaches the intended region while limiting effects outside the focus. This matters because HIFU may generate heating, mechanical stress, or cavitation, and each can alter the target differently. Precise targeting therefore supports controlled interventions and is especially important for image-guided procedures and the development of minimally invasive bioengineering systems.
Image guidance supports the use of HIFU for ablation by helping direct the focused energy toward a selected tissue region. The procedure relies on accurate targeting so that the intended localized effect is applied where needed. This combination of imaging and focused treatment is relevant to bioengineering efforts aimed at developing minimally invasive interventions and therapeutic device designs.
HIFU can support drug and gene delivery by applying a focused acoustic effect to a selected region. Its remote, localized action provides a way to target delivery-related interventions without requiring the same degree of invasive access as direct procedures. In bioengineering, this application motivates the design of systems that coordinate acoustic focusing with delivery strategies.
HIFU is used in bioengineering as an approach for blood-brain barrier modulation and focused stimulation, two applications that depend on directing acoustic effects to a defined region. These uses extend beyond tissue ablation and illustrate the range of outcomes possible through controlled energy delivery. They also guide the development of therapeutic devices and experimental tissue models.
HIFU provides a controllable platform for studying how localized acoustic energy interacts with tissue or other materials. By varying acoustic power, exposure time, tissue properties, and targeting accuracy, researchers can examine different treatment outcomes. This supports therapeutic device development, image-guided interventions, and tissue models designed to represent focused heating, mechanical stress, or cavitation.