Annulus Fibrosus

The annulus fibrosus is the tough, multilayered outer ring of an intervertebral disc that surrounds and contains the gel-like nucleus pulposus. Its concentric layers of collagen fibers are arranged at alternating angles, allowing the disc to resist tension, torsion, and compression while permitting controlled movement between adjacent vertebrae. In biology and spinal research, the annulus fibrosus is studied to understand disc development, biomechanics, degeneration, and herniation. Damage or weakening can allow the nucleus pulposus to protrude, contributing to pain and impaired function, while knowledge of its structure supports research into diagnosis, biomaterials, and disc regeneration.

Annulus Fibrosus - Related Videos

Research

JoVE Journal - Medicine

A Suture Technique for Ruptured Annulus Fibrosus Following Decompression Under Percutaneous Transforaminal Endoscopic Discectomy

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Cited by 2 •

2024

This protocol describes an innovative suture technique for ruptured annular fibrosus during percutaneous transforaminal endoscopic discectomy.

Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation

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2025

Source: Wang, L., et.al. Full-Endoscopic Isolation Zone Technique for the Treatment of Lumbar Disc Herniation. J. Vis. Exp.(2023)This video demonstrates a minimally invasive endoscopic procedure to treat lumbar disc herniation by removing the protruded nucleus pulposus and ruptured annulus fibrosus. The technique decompresses the affected nerve root, alleviates pain, and restores nerve function through targeted tissue resection and radiofrequency modulation.

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

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Cited by 22 •

2017

Whole organ culture of the intervertebral disc (IVD) preserves the native extracellular matrix, cell phenotypes, and cellular-matrix interactions. Here we describe an IVD culture system using mouse lumbar and caudal IVDs in their functional spinal units and several applications utilizing this system.

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury

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Cited by 18 •

2017

Intervertebral disc degeneration is a significant contributor to back pain and a leading cause of disability worldwide. Numerous animal models of intervertebral disc degeneration exist. We demonstrate an ovine model of intervertebral disc degeneration, utilizing a drill bit, which achieves a consistent disc injury and reproducible level of disc degeneration.

Research

JoVE Journal - Biology
Free Sample

Phase Contrast and Differential Interference Contrast (DIC) Microscopy

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Cited by 25 •

2008

This protocol highlights the principles and practical applications of Phase and Differential Interference Contrast (DIC)...

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