Calvaria

The calvaria is the dome-shaped upper portion of the skull that encloses and protects the brain while providing a framework for the scalp and cranial tissues. It is formed mainly by flat bones, including the frontal, parietal, and upper occipital bones, which develop through intramembranous ossification and meet at fibrous sutures that accommodate growth during development. In biology and medicine, calvarial anatomy helps explain skull growth, craniofacial development, and the consequences of head injury. Its accessible bone structure also makes it a useful model for studying bone healing, graft integration, and regenerative tissue-engineering strategies.

Calvaria - Related Videos

Research

JoVE Journal - Cancer Research

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

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Cited by 3 •

2020

The ex vivo culture of bone explants can be a valuable tool for the study of bone physiology and the potential evaluation of drugs in bone remodeling and bone diseases. The presented protocol describes the preparation and culture of calvarias isolated from newborn mice skulls, as well as its applications.

Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening

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Cited by 9 •

2018

This manuscript describes a murine calvarial osteolysis model by exposure to CoCrMo particles, which constitutes an ideal animal model for assessing the interactions between wear particles and various cells in aseptic loosening.

Modulating Cortical Excitability in a Rat Using Repetitive Transcranial Magnetic Stimulation

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2025

Source: Beom, J., et al. Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain. J. Vis. Exp. (2016)This video demonstrates the application of repetitive transcranial magnetic stimulation (rTMS) in anesthetized rats to modulate cortical excitability. The procedure involves determining the motor threshold (MT) to establish baseline stimulation, followed by applying rTMS at an intensity above the MT to induce neuronal depolarization. This stimulation triggers...

Calvarial Window Generation in Mouse Model: A Surgical Procedure to Create Window in the Top Part of the Mouse Skull

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2023

In this video, we describe the surgical procedure to create a calvarial window for accessing the brain of a mouse model.

Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain

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Cited by 10 •

2016

We applied repetitive transcranial magnetic stimulation (rTMS) to the unilateral hemisphere of rat brain, by placing a 25-mm figure-8 coil 1 cm lateral to the vertex on the biauricular line and angulating the coil by 45°. An in-house water cooling system was used for rTMS for more than 20 min.

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