Contractures

Contractures are persistent limitations in joint movement caused by shortening or stiffening of muscles, tendons, ligaments, joint capsules, or surrounding connective tissue, making them important indicators of altered musculoskeletal function. They develop when prolonged immobilization, scarring, inflammation, tissue injury, or abnormal muscle activity promotes collagen remodeling and loss of tissue extensibility, so a joint cannot reach its normal range even when a person attempts to move it. In biology and medicine, studying contractures helps researchers distinguish structural restriction from temporary muscle spasticity, evaluate how disease or injury changes tissues, and assess interventions such as stretching, positioning, physical therapy, and surgery. Their progression can reduce mobility, impair posture, and limit independence.

Contractures - Related Videos

Research

JoVE Journal - Medicine

Holmium:YAG Laser-Assisted Induction of Bladder Neck Contracture in a Rat Model

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2026

This protocol demonstrates transvesical Ho:YAG laser ablation to create a reproducible rat model of bladder neck fibrosis for studying thermal injury-induced fibrotic remodeling and therapeutic interventions.

Using a Knee Arthrometer to Evaluate Tissue-specific Contributions to Knee Flexion Contracture in the Rat

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Cited by 4 •

2018

The goal of the protocol is to measure the extension range of motion of the rat knee. The effects of various diseases that increase the stiffness of the knee joint and the effectiveness of treatments can be quantified.

A Mini-Invasive Internal Fixation Technique for Studying Immobilization-Induced Knee Flexion Contracture in Rats

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Cited by 1 •

2019

Here, we present a protocol to describe a minimally invasive technique for knee joint immobilization in a rat model. This reproducible protocol, basing on muscle-gap separation modus and the mini-incision skill, is suitable for studying the underlying molecular mechanism of acquired joint contracture.

Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice

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Cited by 14 •

2015

Murine left ventricular papillary muscle can be used to investigate cardiac contractility in vitro. This article describes in detail the isolation and experimental protocols to study cardiac contractile characteristics.

Research

JoVE Journal - Medicine
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Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

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Cited by 1 •

2025

Intrauterine adhesions (IUAs), the most common pathological consequence of endometrial injury, severely impair reproductive function. Trauma and infection are widely recognized as key risk factors for IUA development. We have successfully established a reproducible rat model of IUAs by combining two critical injury methods: mechanical curettage and infectious induction with lipopolysaccharide.

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