Cystic Duct Obstruction
Cystic Duct Obstruction - Related Videos
08:56
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Cited by 300 •
2015
Disruption of bile flow results in severe inflammatory cholestatic liver injury with a characteristic time-dependent sequence of morphological alterations. Here we present a protocol for the surgical ligation of the common bile duct in mice that allows to induce a strong fibrotic response after 21 to 28 days.
07:30
Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
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Cited by 11 •
2017
The goal of this protocol is to present transcanalicular laser-assisted dacryocystorhinostomy as a minimally invasive approach in the treatment of primary acquired nasolacrimal duct obstruction.
04:02
Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture
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2025
The integrated technique described in this protocol achieves real-time biliary mapping via indocyanine green (ICG) fluorescence, minimally invasive stone clearance under direct visualization, and secure primary duct repair (6-0 PDS), eliminating T-tube drainage.
03:51
Treatment of Ejaculatory Duct Obstruction by Seminal Vesiculoscopy Assisted Flow Modification
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Cited by 2 •
2023
This protocol introduces the clinical application of seminal vesicle endoscopy combined with holmium laser in the treatment of ejaculatory duct obstruction caused by ejaculatory duct cyst.
11:52
Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea
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Cited by 17 •
2012
Here we demonstrate our protocol for isolation of basal and submucosal gland duct cells from mouse tracheas. We also demonstrate the method of injecting stem cells into the dorsal mouse fat pad to create an in vivo model of submucosal gland regeneration.
FAQs
When the cystic duct stays blocked, bile remains within the gallbladder instead of leaving normally. The retained contents contribute to gallbladder distention, while the obstruction also permits chemical irritation of the organ. These local effects explain why the process is not simply a change in bile flow: they can create conditions that lead to inflammation and worsening symptoms.
Acute cholecystitis represents an inflammatory consequence of the obstruction rather than the blockage alone. Distention and chemical irritation can affect the gallbladder wall, producing this inflammatory state. Recognizing that progression matters because persistent obstruction may also promote infection and other complications, making the duration and effects of blockage relevant to clinical assessment.
At the biology level, the key disturbance is loss of normal communication between gallbladder storage and biliary outflow. Bile needs a patent channel to leave the gallbladder; obstruction interrupts that movement and changes the organ’s local conditions. This links a duct-level event with organ-level effects, including distention, irritation, inflammation, and impaired biliary function.
Evaluation is particularly relevant when right upper abdominal pain occurs with nausea or when pain follows fatty meals. These findings do not by themselves establish the cause, but they help clinicians connect the patient’s symptoms with possible gallbladder dysfunction. Clinical assessment then works with imaging to investigate whether biliary obstruction and its consequences are present.
Ultrasound is specifically identified as an important imaging approach for assessing suspected biliary obstruction. It complements clinical assessment, which considers symptoms and their pattern, and helps support decisions about the next step. In this context, imaging is used to investigate the suspected process and its effects rather than relying on symptoms alone.
Clinical assessment and imaging help support treatment decisions, which may include removing the obstructing stone or performing gallbladder surgery. The management plan addresses the blockage and its effects on biliary function. Persistent obstruction, inflammation, infection, or complications can make treatment planning particularly important because the condition may extend beyond an isolated disturbance in bile flow.