Fibula Bone
Fibula Bone - Related Videos
01:10
Bones of the Lower Limb: Tibia and Fibula
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2025
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
08:49
Models of Bone Metastasis
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Cited by 115 •
2012
Animal models are frequently utilized to study cancer metastasis to bone. In this protocol we will describe two common methods of tumor inoculation for bone metastasis studies and briefly describe some of the analyses utilized to monitor and quantify these models.
11:05
Generation and Identification of GM-CSF Derived Alveolar-like Macrophages and Dendritic Cells From Mouse Bone Marrow
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Cited by 18 •
2016
Bone marrow cells cultured with granulocyte macrophage colony stimulating factor (GM-CSF) generate a heterogeneous culture containing macrophages and dendritic cells (DCs). This method highlights using MHCII and hyaluronan (HA) binding to differentiate macrophages from the DCs in the GM-CSF culture. Macrophages in this culture have many similarities to alveolar macrophages.
11:25
Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice
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Cited by 33 •
2015
We describe a protocol whereby busulfan conditioning permits the bone marrow of a recipient mouse to be replaced with bone marrow cells from donor mice ubiquitously expressing green fluorescent protein, in the absence of irradiation. This technique is useful to study bone marrow cell accumulation in the central nervous system.
07:17
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
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Cited by 293 •
2016
Here we present a protocol for the dissection of hind limb long bones (femurs and tibiae) from the laboratory mouse. We further describe a rapid technique for bone marrow isolation from these bones that utilizes centrifugation for removal of bone marrow from the bone marrow space.
FAQs
Its expanded distal end forms the lateral malleolus, a bony structure that helps guide and stabilize the ankle joint. The fibula also articulates with the tibia at its proximal end, so its position parallel to the tibia contributes to the organized framework of the lower leg and ankle region.
The fibula has a compact outer cortex surrounding spongy bone and marrow, an arrangement characteristic of long bones. Examining these regions helps relate skeletal structure to broader biological topics, including bone composition, internal organization, and the way long bones are studied in anatomy and biology.
Although the fibula bears less body weight than the tibia, the two bones function as a paired lower-leg framework. The fibula contributes to leg structure, provides sites for muscle attachment, and supports ankle stability. Together, these roles connect skeletal anatomy with movement and locomotion.
Because the fibula is a long bone with compact cortex, spongy bone, and marrow, it provides a useful structure for studying long-bone biology. Its anatomy can support investigations of skeletal growth and development, while its articulations and ankle relationship connect those processes with functional lower-limb anatomy.
The fibula’s position, articulations, and contribution to ankle stability make it relevant to the study of fracture patterns. Examining how fibular tissue relates to the tibia and lateral malleolus helps place an injury within the larger anatomy of the lower leg and ankle rather than considering the bone in isolation.
The fibula bears less body weight than the tibia, which allows its tissue to support selected reconstructive procedures. This application reflects the balance between structural contribution and relative load-bearing demand. Studying the bone therefore connects basic skeletal biology with medical approaches that use fibular tissue for reconstruction.