Hyperglycemia
Hyperglycemia - Related Videos
13:35
Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules
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Cited by 25 •
2017
This work describes methods to establish acute and chronic hyperglycemia models in zebrafish. The aim is to investigate the impact of hyperglycemia on physiological processes, such as constitutive and injury-induced neurogenesis. The work also highlights the use of zebrafish to follow radiolabeled molecules (here, [18F]-FDG) using PET/CT.
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Hyperglycemia
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2026
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
05:49
Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
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Cited by 6 •
2021
This protocol noninvasively induces hyperglycemia in zebrafish for up to 8 weeks. Using this protocol, an in-depth study of the adverse effects of hyperglycemia can be made.
09:35
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
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2024
This study presents a protocol for establishing a highly reproducible animal model of hemorrhagic transformation (HT) using middle cerebral artery occlusion/reperfusion (MCAO/R) in C57BL/6 mice with acute hyperglycemia.
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Improving IV Insulin Administration in a Community Hospital
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Cited by 7 •
2012
When compared to the previous paper protocol, implementation of a computerized glucose management system results in a substantial increase in blood glucose concentration measurements within the target range. Using a computerized glucose management system to monitor blood glucose levels, decreases in severe hypoglycemia (<40 mg/dL), clinical hypoglycemia (<70 mg/dL), and hyperglycemia (>180 mg/dL) also can be observed.
FAQs
Two mechanisms can raise glucose levels: inadequate insulin production or reduced cellular response to insulin limits glucose uptake, while glucose production by the liver can exceed cellular use. These processes may occur together, worsening disruption of energy balance. Distinguishing their contributions helps researchers analyze glucose homeostasis, insulin resistance, and metabolic disease mechanisms.
Pancreatic beta cells are central because they produce insulin, the signal that promotes glucose uptake by cells. If beta-cell function is insufficient, glucose remains elevated even when glucose is available in the circulation. Biological studies therefore examine beta-cell activity alongside insulin action to clarify how impaired regulation contributes to metabolic dysfunction and diabetes-related changes.
Elevated blood glucose indicates that glucose availability exceeds the capacity for effective cellular uptake or use. This mismatch affects energy balance because cells do not handle circulating glucose normally, while the increased glucose concentration also disturbs osmotic regulation. Studying both consequences connects blood glucose control with broader cellular and physiological changes.
Insulin resistance refers to insufficient cellular response to insulin, so glucose uptake does not increase appropriately even when insulin is present. The resulting elevation in circulating glucose makes insulin action a key focus of hyperglycemia research. Comparing insulin production with insulin responsiveness helps separate pancreatic limitations from defects in how target cells use the signal.
Researchers combine biological models with clinical measurements to examine glucose regulation and its consequences. Models can be used to study pancreatic beta-cell function, insulin resistance, and tissue responses, while measurements track blood glucose and related changes in glucose homeostasis. Together, these approaches connect controlled investigation with observations relevant to disease mechanisms and treatment evaluation.
Studies of prolonged high glucose help investigators examine how abnormal glucose exposure affects cells and organs over time. By evaluating tissue responses in biological models or clinical contexts, researchers can connect disrupted glucose regulation with impaired cellular and organ function. These findings support a more detailed understanding of diabetes-related biology rather than focusing only on glucose measurements.
Treatment studies use hyperglycemia as a context for testing whether glucose regulation improves when insulin production, insulin action, or excessive liver glucose production is addressed. Researchers can assess changes through clinical measurements and biological models, then examine related effects on tissues and cellular function. This approach links treatment performance with the underlying mechanism being targeted.