Inflammation
Inflammation - Related Videos
01:38
Inflammation
0 Views •
2019
Overview In response to tissue injury and infection, mast cells initiate inflammation. Mast cells release chemicals that increase the permeability of adjacent blood capillaries and attract additional immune cells to the wound or site of infection. Neutrophils are phagocytic leukocytes that exit the bloodstream and engulf invading microbes. Blood clotting platelets seal the wound and fibers create a scaffold for wound healing. Macrophages engulf aging neutrophils to end the acute inflammatory...
07:10
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
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Cited by 25 •
2013
We describe a non-invasive imaging method for distinguishing inflammatory stages. Systemic delivery of luminol reveals areas of acute inflammation dependent upon MPO activity in neutrophils. In contrast, injection of lucigenin allows for visualization of chronic inflammation dependent upon Phox activity in macrophages.
08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
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Cited by 11 •
2015
Although Candida infection models are available to study host immune resistance, a model to study T cell mediated immunopathology in the context of Candida infection is absent. Here we describe a method to establish Th17 immunopathology associated with oral Candida infection in immunodeficient mice.
03:06
A Method to Induce Ocular Surface Inflammation in a Murine Model
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2025
This video demonstrates a method to induce ocular surface inflammation and meibomian gland dysfunction in a murine model. Stimulation of the mouse's immune system using an immunogen and later restimulation with the same immunogen promotes ocular surface inflammation, which causes plugging of meibomian gland secretion through neutrophil-produced aggNETs and leads to dry eye disease.
01:28
Inflammation: Introduction
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2026
Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
FAQs
Cytokines and histamine act as signaling molecules that coordinate activity between damaged tissues and immune cells. Their release helps initiate local changes in blood vessels and directs defensive activity toward the affected area. This coordination connects detection of infection or injury with the cellular responses needed for pathogen removal and the early stages of tissue repair.
Increased blood flow delivers more circulating resources to the affected tissue, while greater vascular permeability allows defensive cells and other components to leave the circulation and enter the site of damage. Together, these changes make local immune activity possible and support the removal of harmful stimuli. They also help create conditions in which tissue restoration can begin.
Acute inflammation is generally associated with a temporary response that supports pathogen removal and tissue repair. By contrast, persistent inflammation continues over time, and dysregulated inflammation is not properly controlled. These prolonged or misdirected responses can injure healthy tissue rather than restoring it, helping explain why inflammatory biology is relevant to chronic disease and autoimmune disorders.
Inflammation is beneficial when its signals and cellular activity remain appropriately directed and limited. If regulation becomes persistent or dysregulated, the same defensive response can extend beyond the original harmful stimulus and affect healthy tissue. This shift from protective activity to tissue damage is important for understanding how abnormal immune regulation contributes to disease and why control of inflammation matters.
Biological studies of inflammation examine how immune regulation, signaling molecules, blood-vessel changes, and tissue responses work together after infection or injury. This framework allows researchers to connect defensive activity with pathogen removal and restoration of tissue integrity. It also supports comparisons between effective acute responses and prolonged responses that may interfere with healing or harm tissue.
Inflammation research helps explain how immune responses become misdirected in autoimmune disorders and how persistent activity may contribute to chronic disease. These insights inform the development of anti-inflammatory therapies designed to reduce harmful inflammation while preserving the protective functions needed for infection control and tissue repair. The work therefore links basic biology with efforts to improve disease management.