Jejunum

The jejunum is the middle section of the small intestine, linking the duodenum to the ileum and serving as a major site of nutrient absorption. Its folded lining, composed of circular folds, villi, and microvilli, greatly increases surface area, while epithelial transport proteins move digested sugars, amino acids, ions, and other nutrients into the blood or lymph. Intestinal contractions mix chyme with digestive secretions and propel it toward the ileum, supporting efficient absorption. Studying the jejunum helps explain human digestion, nutrient metabolism, medication uptake, and disorders such as malabsorption, inflammation, and intestinal obstruction.

Jejunum - Related Videos

Research

JoVE EoE - Antibody-Based Technologies

An Immunofluorescence-Based Method for Visualizing Tuft Cells in Jejunum Cryosections

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2025

This video illustrates an immunofluorescence-based method for visualizing intestinal tuft cells in free-floating mouse jejunum cryosections. Within the intestinal villi, the co-localization of green fluorescence at the luminal tip with an extended red rootlet mass indicates the presence of tuft cells.

Recording of Mesenteric Afferent Nerve Activity in an Ex Vivo Mouse Jejunum Segment

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2025

This video shows the process of recording electrical signals from mesenteric afferent nerves in a dissected mouse jejunal segment to study the effects of tissue pressure and movement changes on afferent nerve activity.

Research

JoVE Journal - Biology
Free Sample

Use of Anti-phospho-girdin Antibodies to Visualize Intestinal Tuft Cells in Free-Floating Mouse Jejunum Cryosections

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Cited by 3 •

2018

Kuga et al. discovered that phosphorylation-status specific antibodies against the actin binding protein girdin phosphorylated at tyrosine 1798 (pY1798) can be used to label tuft cells (TCs). This protocol allows robust visualization of TCs using immunofluorescent staining of free-floating jejunum cryosections with pY1798 antibodies.

Research

JoVE Journal - Medicine
Free Sample

Intraoperative Video Consultation Following Bile Duct Transection Facilitates Direct OR Transfer for Robotic Hepaticojejunostomy at Tertiary Center

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2026

Intraoperative video consultation expedites and improves surgical care. Here, we present a case where intraoperative video consultation between a rural hospital and an academic hepatobiliary surgeon facilitated immediate diagnosis of bile duct transection during laparoscopic cholecystectomy, direct to operating room transfer between centers, and injury repair with robotic-assisted Roux-en-Y hepaticojejunostomy.

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis

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2025

This protocol presents a method for performing a parenchymal sparing robotic-assisted lateral pancreaticojejunostomy intended for appropriately selected patients with a pancreatic duct obstruction without significant inflammation of the pancreatic head. This article demonstrates critical aspects of the operation in a minimally invasive, robotic fashion to treat recurrent acute/chronic pancreatitis.

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