Lung Transplantation
Lung Transplantation - Related Videos
08:22
Orthotopic Left Lung Transplantation in Rats
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Cited by 1 •
2025
This protocol describes an improved technique for orthotopic left lung transplantation in rats, focusing on reducing operational difficulty and improving survival rates.
05:49
Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation
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Cited by 5 •
2023
Here, we describe the necessary steps for establishing a rat EVLP model and show the inflammatory profile associated with the perfused lungs. The aim is to propagate knowledge and experiences about the rat EVLP model, enabling the integral understanding of the biological responses associated with that revolutionary technique.
10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
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Cited by 20 •
2012
Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust preclinical model precludes examining obliterative bronchiolitis immunopathogenesis. Unlike other solid organ transplants, vascularized mouse lung transplantation has only recently been developed. Here we show our independently developed obliterative bronchiolitis model after murine orthotopic single-lung transplantation.
06:16
Rat Heterotopic Abdominal Heart/Single-lung Transplantation in a Volume-loaded Configuration
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2015
We describe a novel technique for heterotopic abdominal heart-lung transplantation (HAHLT) in rats. The transplant configuration results in a partially loaded graft circulation, allowing direct functional assessment. This model may be employed for acute or chronic studies of function and immunologic status of the transplanted graft.
07:28
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation
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2024
This protocol describes a new method for effectively reconstructing donor atrial cuff anterior wall defects during lung transplantation through the rotation of the donor posterior atrial flap.
FAQs
Donor tissue can trigger T-cell-mediated recognition, which identifies transplanted cells as foreign and can initiate rejection. Immunosuppressive medicines reduce this immune response, helping protect the graft after implantation. This mechanism explains why transplantation requires ongoing attention to immune activity rather than relying on surgical connection alone, and why rejection remains a central biological concern.
Compatibility between donor and recipient influences how readily the recipient’s immune system responds to the graft. Better matching can support transplant success, whereas incompatibility may increase concern about rejection and complicate long-term management. In lung transplantation, compatibility is considered alongside disease severity and the need for continued monitoring.
Long-term graft function depends on controlling two opposing threats: rejection from immune recognition and infection. Monitoring for acute or chronic rejection and maintaining infection prevention are therefore complementary strategies during immunosuppressive treatment. This balance illustrates how lung transplantation links immunology with respiratory biology, because care must protect donor tissue while supporting the recipient’s overall health.
Surgeons connect the donor airways and blood vessels to the recipient’s corresponding remaining structures. These connections allow the implanted lung to integrate with the recipient’s respiratory system and support restoration of respiratory function. Their success is a key surgical component, because the biological benefits of transplantation depend on establishing both airway continuity and vascular continuity after diseased tissue is replaced.
Selection focuses on carefully chosen patients with advanced pulmonary disorders whose severe disease no longer responds adequately to conventional treatment. The decision must also account for the management demands that follow transplantation, including compatibility assessment, infection prevention, immunosuppressive treatment, and monitoring for acute or chronic rejection. These considerations connect patient selection with expected long-term care.
Restored respiratory function may improve oxygen exchange, exercise capacity, and quality of life. These gains depend on long-term management rather than surgery alone, because outcomes are influenced by donor-recipient compatibility, infection prevention, and surveillance for acute or chronic rejection. The procedure therefore combines potential functional recovery with continuing biological and clinical monitoring.