Mucosal Damage
Mucosal Damage - Related Videos
08:25
Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice
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Cited by 5 •
2014
A mouse model of human endoscopic skull base reconstruction has been developed that creates a semipermeable interface between the brain and nose using nasal mucosal grafts. This method allows researchers to study delivery to the central nervous system of high molecular weight therapeutics which are otherwise excluded by the blood-brain barrier when administered systemically.
02:55
Quantification of Immune Mediator Levels in Human Mucosal Lining Fluid
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2025
This video demonstrates the quantification of immune mediator levels in neonatal human nasal mucosal lining fluid extract. An electrochemiluminescence-based multiplex assay system measures these mediators by evaluating the intensity of emitted light when they are excited.
01:25
Mucosal Barrier of the Stomach
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2024
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl. Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
12:16
Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
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Cited by 3 •
2015
This manuscript describes the production, characterization and potential uses of a tissue engineered 3D esophageal construct prepared from normal primary human esophageal fibroblast and squamous epithelial cells seeded within a de-cellularized porcine scaffold. The results demonstrate the formation of a mature stratified epithelium similar to the normal human esophagus.
05:31
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Cited by 4 •
2017
This protocol describes a noninvasive technique for the sampling of undisturbed mucosal lining fluid from the upper airways. It can be used to perform the quantification of in vivo levels of protein mediators, such as cytokines and chemokines, in subjects of all ages.
FAQs
These stresses can injure epithelial cells directly or disrupt the conditions that maintain the mucosal surface. Cell injury may weaken the junctions connecting neighboring epithelial cells, while inflammation can further compromise tissue integrity. The resulting barrier failure increases permeability and allows irritants or microorganisms to reach underlying layers, linking surface damage with deeper biological responses.
Epithelial cell junctions help maintain continuity between adjacent cells and limit movement across the tissue. When injury weakens these connections, the mucosal barrier becomes less selective and tissue permeability rises. This change provides a mechanistic link between epithelial disruption and the access of irritants or microorganisms to underlying layers.
Barrier disruption can expose underlying tissue to irritants or microorganisms that would normally be restricted by intact epithelium. This exposure helps connect mucosal injury with inflammatory responses and infectious processes. Studying these relationships allows biology and biomedical research to examine how epithelial damage influences host defense and disease mechanisms.
The underlying concern is similar across gastrointestinal, respiratory, and reproductive tracts: injury can compromise epithelial barrier integrity and increase permeability. However, research can examine these effects within each tract’s biological setting. Comparing sites helps clarify how a shared barrier problem relates to different patterns of inflammation, infection, tissue repair, and host defense.
Investigations focus on how epithelial injury, weakened cell junctions, increased permeability, inflammation, infection, and repair are related. Researchers can use this framework to examine disease mechanisms and determine whether an intervention preserves or restores epithelial barrier integrity. The central outcome is a clearer connection between tissue disruption and biological function.
Mucosal damage provides a context for assessing whether therapeutic strategies or other interventions protect the epithelial barrier or support its restoration. Such evaluation is relevant because barrier integrity influences exposure of underlying layers to irritants and microorganisms. Findings can inform understanding of disease mechanisms, tissue repair, and host defense without treating injury as an isolated surface event.