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Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice
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Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

DOI:
10.3791/51452-v

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08:25 min

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July 16, 2014

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, ,
1Department of Biomedical Engineering,Boston University, 2Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary,Harvard Medical School

Chapters

  • 00:05Title
  • 01:29Harvesting of the Mucosal Graft
  • 02:43Surgical Implantation of Mucosal Graft
  • 04:49Administration of Dosing Solution
  • 06:44Analysis of Transmucosal Delivery
  • 07:32Results: Fluorescent Microscope Image of a Mouse Brain Slice Following Transmucosal Dosing
  • 07:57Conclusion

Summary

Automatic Translation

Automatic Translation

A mouse model of human endoscopic skull base reconstruction has been developed that creates a semipermeable interface between the brain and nose using nasal mucosal grafts. This method allows researchers to study delivery to the central nervous system of high molecular weight therapeutics which are otherwise excluded by the blood-brain barrier when administered systemically.

Tags

Mucosal EngraftingBrain Drug DeliveryBlood-brain Barrier BypassNasal MucosaTranscranial CatheterSurgical BBB DefectPreclinical TestingNeurological DiseasePsychiatric Disease

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