Native Kidney Removal
Native Kidney Removal - Related Videos
08:19
The Mouse Isolated Perfused Kidney Technique
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Cited by 24 •
2016
The mouse isolated perfused kidney (MIPK) is a technique for keeping a mouse kidney under ex vivo conditions perfused and functional for 1 hr. The buffers and surgical technique are described in detail.
05:36
Kidney Procurement in a Preclinical Large Animal Model
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2025
Here, we present a protocol that details a surgical model for kidney procurement in a preclinical swine model for subsequent machine perfusion or transplantation.
10:42
Normothermic Machine Perfusion of Rat Kidneys for Transplantation
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2026
This protocol describes the ex vivo normothermic machine perfusion of a rat kidney for subsequent transplantation into a recipient rat.
01:45
Kidney Structure
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2019
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries. The renal cortex is the thick outer layer of the kidney. It...
03:14
Vibratome Sectioning of Whole Murine Kidney: A Technique to Generate Thin Sections of Murine Kidney
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2023
In this video, we demonstrate the vibratome sectioning of a whole mouse kidney to obtain thin slices. These sliced tissue sections can be stored at low temperatures until further downstream analysis.
FAQs
Removing one kidney changes the amount of renal tissue available for filtration and homeostatic regulation, while removing both eliminates the function of the original kidneys. The resulting physiological effect depends on how much renal function remains and, in transplantation, on whether the graft performs adequately. This distinction is central when evaluating fluid balance and filtration after surgery.
The renal blood vessels supply and drain the kidney, while the ureter carries urine away from it. Dividing these structures separates the organ from the urinary and circulatory systems so it can be excised. Their involvement explains why the procedure directly affects filtration, urine drainage, and the kidney’s contribution to whole-body homeostasis.
In transplantation-related biology, removing a native kidney can create physical space for the transplanted organ or reduce problems caused by a diseased or enlarged kidney. It may also eliminate a native-kidney source of infection or malignancy. The decision therefore connects surgical anatomy with the goal of protecting the transplant environment and improving clinical management.
The main determinants are whether one or both native kidneys are removed, how much renal function remains, and, after transplantation, how well the graft performs. These factors influence the body’s ability to maintain filtration, fluid balance, and homeostasis. Consequently, the same operation can have different biological consequences in different transplantation settings.
The procedure requires surgeons to isolate the kidney’s renal blood vessels and ureter, divide those connections, and then excise the organ. The kidney is removed through an operative approach selected for the patient. This sequence reflects the organ’s anatomical attachments and provides a framework for understanding how surgical access and disconnection support nephrectomy.
Native nephrectomy may be used when an original kidney is diseased or enlarged, or when it represents a source of infection or malignancy. In these situations, removal addresses a problem associated with the native organ itself rather than serving only an anatomical purpose. The indication links kidney pathology to decisions made in transplantation-related care.
Postoperative kidney function must be considered in relation to both the remaining renal tissue and the transplanted graft. If native function is reduced or absent, graft performance becomes especially important for maintaining filtration, fluid balance, and homeostasis. This relationship makes native kidney removal relevant to biological studies of organ replacement and functional recovery.