Olfactory Regeneration
Olfactory Regeneration - Related Videos
06:32
Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
0 Views •
2017
Olfactory sensory neurons express a wide variety of axon-sorting molecules to establish proper neural circuitry. This protocol describes an immunohistochemical staining method to visualize combinatorial expressions of axon-sorting molecules at the axon termini of olfactory sensory neurons.
09:00
Olfactory Behavioral Testing in the Adult Mouse
0 Views •
Cited by 68 •
2009
Fundamental, yet unique properties of the rodent olfactory system have led to its increasing study among biologists. A relatively simple assessment of its function is then also needed. Here we describe sensitive tests for the characterization of mouse olfactory sensitivity and preference.
08:42
Whole Mount Labeling of Cilia in the Main Olfactory System of Mice
0 Views •
Cited by 13 •
2014
Cilia of olfactory sensory neurons contain proteins of the signal transduction cascade, but a detailed spatial analysis of their distribution is difficult in cryosections. We describe here an optimized approach for whole mount labeling and en face visualization of ciliary proteins.
06:40
Simple and Computer-assisted Olfactory Testing for Mice
0 Views •
Cited by 9 •
2015
We present a simple and unbiased olfactory test in mice. With this protocol olfactory discrimination, preference, avoidance and sensitivity to a novel odor as compared to water can be assessed in single behavioral sessions. This method is indicated for a single experimenter and analysis is based on computer-assisted video processing.
06:16
Electrophysiological Measurements from a Moth Olfactory System
0 Views •
Cited by 11 •
2011
Insect olfactory systems provide unique opportunities for recording odorant-induced responses in the forms of electroantennograms (EAG) and single sensillum recordings (SSR), which are summed responses from all odorant receptor neurons (ORNs) located on the antenna and from those housed in individual sensilla, respectively.
FAQs
Basal stem and progenitor cells provide the renewing cell population within the olfactory epithelium. Their division supplies new cells that can differentiate into olfactory sensory neurons or supporting cells. This coordinated production is important because regeneration requires both replacement of smell-sensing neurons and restoration of the cellular environment in which those neurons function.
Replacement neurons must extend axons from the olfactory epithelium to the olfactory bulb, a brain region involved in processing olfactory information. Reestablishing these neural connections links cell replacement with recovery of sensory signaling. Without this connection step, producing new sensory cells alone would not fully restore the smell-sensing pathway.
The process provides a biological example of nervous tissue renewing after damage. Studying how sensory neurons are replaced and reconnect with the olfactory bulb can help explain cellular repair mechanisms that are difficult to observe in many other neural systems. This makes the olfactory pathway relevant to broader research on neural regeneration.
Research commonly considers damage associated with injury, infection, toxic exposure, or aging because these conditions can affect the smell-sensing system. Examining regeneration in these contexts helps connect cellular renewal with sensory loss and recovery. It also frames olfactory regeneration as a response relevant to both environmental damage and biological decline.
A study can trace several linked events: division of basal stem and progenitor cells, differentiation into sensory neurons or supporting cells, axon extension toward the olfactory bulb, and reestablishment of neural connections. Following this sequence helps researchers relate changes at the cellular level to the maintenance or restoration of odor detection.
Because the process supports restoration of odor detection, it provides context for investigating sensory loss and possible approaches to neural repair. Findings can also inform stem cell biology by showing how progenitor cells generate specialized neural and supporting cell types. These connections make the topic relevant to efforts aimed at restoring olfactory function.