Periodontal Ligament
Periodontal Ligament - Related Videos
04:14
Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films
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2019
Here, we present protocols of culturing human periodontal ligament (PDL) cell spheroids by chitosan films. The culture of three-dimensional (3D) cellular spheroids provides an alternative to conventional tissue culture polystyrene (TCPS) culture system.
07:09
In situ Compressive Loading and Correlative Noninvasive Imaging of the Bone-periodontal Ligament-tooth Fibrous Joint
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Cited by 17 •
2014
In this study, the use of an in situ loading device coupled with micro-X-ray computed tomography for fibrous joint biomechanics will be discussed. Experimental readouts identifiable with an overall change in joint biomechanics will include: 1) reactionary force vs. displacement, i.e. tooth displacement within the alveolar socket and its reactionary response to loading, 2) three-dimensional (3D) spatial configuration and morphometrics, i.e. geometric relationship of the tooth with the alveolar...
10:26
Inducing Apical Periodontitis in Mice
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Cited by 26 •
2019
Here, we present a protocol to locally induce apical periodontitis in mice. We show how to drill a hole in the mouse's tooth and expose its pulp, in order to cause local inflammation. Analysis methods to investigate the nature of this inflammation, such as micro-CT and histology, are also demonstrated.
08:03
Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
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Cited by 7 •
2017
We present a model of ligament tissue in which three-dimensional constructs are treated with the human exercise-conditioned serum and analyzed for collagen content, function, and cellular biochemistry.
10:32
Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
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Cited by 11 •
2015
Animal models are important tools for the evaluation of tissue-engineered grafts. This paper presents the protocol for preparing an electrospun biodegradable polymer graft for use in anterior cruciate ligament tissue engineering, as well as a surgical protocol for implantation in a rat model.
FAQs
Its cells continuously remodel the collagen-rich matrix, responding to mechanical forces generated during chewing or orthodontic loading. This remodeling changes how forces move through the tooth-supporting tissues and helps maintain an appropriate balance between tooth stability and controlled movement. The same adaptability makes the ligament important for studying changes caused by altered loading.
These attachments create a continuous mechanical connection between the tooth and its surrounding bone. As bite forces reach the ligament, the collagen-rich fiber system helps distribute those forces rather than concentrating them at a single interface. This arrangement supports tooth stability while still permitting the controlled movement required during changing mechanical conditions.
Orthodontic pressure alters the mechanical environment around a tooth, prompting periodontal ligament cells to remodel their surrounding matrix. The resulting response is linked to changes in alveolar bone formation and resorption, allowing the tooth to shift rather than remain fixed. Studying this process helps explain how orthodontic treatment can guide tooth position.
Mechanical support is only one aspect of periodontal ligament activity. The tissue also contributes to sensation and nutrition, giving it functional importance beyond connecting tooth and bone. Considering these roles together helps biology researchers evaluate the ligament as a living, responsive tissue rather than as a passive structural layer surrounding the tooth.
The ligament is part of the tooth-supporting system whose stability depends on organized connective tissue and ongoing matrix remodeling. Studying its structure and behavior therefore helps researchers understand how periodontal disease may affect tooth support. It also provides a biological context for investigating changes in the tissues that anchor teeth to alveolar bone.
Because periodontal ligament cells continually remodel a collagen-rich matrix and respond to mechanical conditions, the tissue offers a relevant system for examining repair of tooth-supporting structures. Research can connect its normal roles in stability, loading, and attachment with wound-healing questions and with strategies intended to regenerate the periodontal ligament, cementum, and surrounding bone.