Rodent Brain

The rodent brain is the central nervous system organ of mice, rats, and related mammals, coordinating sensory processing, movement, learning, emotion, and physiological regulation. Its functions arise from interconnected regions, including the cerebral cortex, hippocampus, hypothalamus, and olfactory bulb, where neurons communicate through electrical impulses and chemical synapses; activity-dependent synaptic plasticity can alter circuit strength during learning and memory. Because its organization supports controlled behavioral, cellular, and molecular studies, the rodent brain is a major model for investigating neural development, cognition, sensory systems, and neurological disease. Findings from these models also inform studies of brain mechanisms and potential therapeutic strategies.

Rodent Brain - Related Videos

Research

JoVE Journal - Neuroscience

Transcranial Electrical Brain Stimulation in Alert Rodents

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Cited by 11 •

2017

This protocol describes a surgical set-up for a permanent epicranial electrode socket and an implanted chest electrode in rodents. By placing a second electrode into the socket, different types of transcranial electrical brain stimulation can be delivered to the motor system in alert animals through the intact skull.

Simultaneous fMRI and Electrophysiology in the Rodent Brain

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Cited by 45 •

2010

We have developed a method for simultaneous functional magnetic resonance imaging and electrophysiological recording in the rodent brain, providing a platform for the investigation of the relationship between neural activity and the blood oxygenation level dependent (BOLD) MRI signal.

Deep Brain Stimulation with Simultaneous fMRI in Rodents

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Cited by 21 •

2014

This protocol describes a standard method for simultaneous functional magnetic resonance imaging and deep brain stimulation in the rodent. The combined use of these experimental tools allows for the exploration of global downstream activity in response to electrical stimulation at virtually any brain target.

Microinjection-Based Delivery of a Therapeutic Agent into an Awake Rodent Brain

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2025

Source: Poland, R. et al. Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior. J. Vis. Exp. (2015)In this video, a water-filled microinjection setup consisting of a syringe and microinjector tubing is used for precise drug delivery. A rat with a pre-implanted guide cannula undergoes targeted brain microinjection, enabling accurate administration of therapeutic agents in awake animals with minimal tissue damage.

Personalized Needles for Microinjections in the Rodent Brain

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Cited by 3 •

2018

We describe here a protocol for microinjection in the rodent brain that uses quartz needles. These needles do not produce detectable tissue damage and ensure reliable delivery even in deep regions. Moreover, they can be adapted to research needs by personalized designs and can be re-used.

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