Sodium Toxicity

Sodium toxicity is the harmful effect of excessive sodium accumulation in an organism, tissue, or environment, making it important in physiology, ecology, and agriculture. In animals, elevated sodium concentration in body fluids increases osmotic pressure and draws water from cells, disrupting hydration, nerve function, and muscle activity; in plants, accumulated sodium can enter cells, disturb ion balance, and interfere with potassium-dependent processes. Studying sodium toxicity helps explain the biological effects of hypernatremia and soil salinity, supports diagnosis of cellular stress, and guides management of saline environments, irrigation practices, and health conditions involving abnormal sodium levels.

Sodium Toxicity - Related Videos

Education

JoVE Core - Anatomy and Physiology

Regulation of Sodium and Potassium

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2024

The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP). Sodium Regulation Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily in...

Research

JoVE Journal - Chemistry
Free Sample

Synthesizing Sodium Tungstate and Sodium Molybdate Microcapsules via Bacterial Mineral Excretion

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2018

This work presents a protocol for manufacture sodium tungstate and sodium molybdate microcapsules via bacteria and their corresponding nanoparticles.

Growth Assays to Assess Polyglutamine Toxicity in Yeast

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Cited by 3 •

2012

This manuscript describes three complementary protocols for assessing the toxicity of polyglutamine (polyQ)-expansion proteins in the yeast Saccharomyces cerevisiae. These protocols can easily be modified to monitor the toxicity of other misfolded proteins in yeast.

Long-term Lethal Toxicity Test with the Crustacean Artemia franciscana

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Cited by 34 •

2012

This study concerns the development and standardization of a valuable methodological protocol to determine long-term (14 days) lethal toxicity exerted by chemical substances, industrial wastewater or sewage and liquid environmental samples on the saltwater crustacean, Artemia franciscana.

Research

JoVE Journal - Neuroscience
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Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

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Cited by 76 •

2010

The intensely studied nematode worm Caenorhabditis elegans can be transgenically engineered to express the human β-amyloid peptide (Aβ). Induced expression of Aβ in C. elegans muscle leads to a rapid, reproducible paralysis phenotype that can be used to monitor treatments that modulate Aβ toxicity.

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