Stroma
Stroma - Related Videos
01:24
Protein Transport to the Stroma
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2023
Chloroplasts are triple membrane structures with an outer membrane, an inner membrane, and a thylakoid membrane, each containing distinct metabolite transporters, membrane translocons, and enzymes. Appropriate sorting and translocating these proteins to their correct membrane systems is essential for chloroplast function. Protein complexes called the translocon of the outer chloroplast membrane or TOC complex, and the translocon of the inner chloroplast membrane or TIC complex mediate the...
07:59
Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
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Cited by 3 •
2021
Portal vein injection of colorectal cancer (CRC) organoids generates stroma-rich liver metastasis. This mouse model of CRC hepatic metastasis represents a useful tool to study tumor-stroma interactions and develop novel stroma-directed therapeutics such as adeno-associated virus-mediated gene therapies.
07:05
Injection of Porcine Adipose Tissue-Derived Stroma Cells via Waterjet Technology
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2021
We present a method of cell injection via needle free waterjet technology coupled with a sequela of post-delivery investigations in terms of cellular viability, proliferation, and elasticity measurements.
07:20
A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
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Cited by 22 •
2020
A novel three-dimensional spheroid model based on the heterotypic interaction of tumor cells and stromal fibroblasts is established. Here, we present coculture of tumor cells and stromal fibroblasts, time-lapse imaging, and confocal microscopy to visualize the formation of spheroids. This three-dimensional model offers a pertinent platform to study tumor-stroma interactions and test cancer therapeutics.
08:40
A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
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Cited by 24 •
2020
This protocol presents a 3D biomimetic model with accompanying fibrotic stromal compartment. Prepared with physiologically relevant hydrogels in ratios mimicking the bio-physical properties of the stromal extracellular matrix, an active mediator of cellular interactions, tumor growth and metastasis.
FAQs
These components contribute different forms of support and regulation. The extracellular matrix provides a structural scaffold, while fibroblasts help maintain that framework. Blood vessels support nutrient delivery, and immune cells participate in signaling and repair. Together, their organization creates a local environment that can influence how specialized tissue cells function and respond to changing conditions.
Organization determines how supportive elements interact with specialized cells and with one another. These relationships can coordinate mechanical support, nutrient delivery, signaling, and repair. During development or regeneration, such coordination helps shape tissue behavior rather than simply providing a passive framework. Consequently, changes in stromal arrangement can affect how tissues form, recover, or maintain function.
The term describes distinct biological settings. In animal tissues, stromal function is associated with extracellular matrix, fibroblasts, vessels, and immune cells surrounding specialized cells. In chloroplasts, the stroma is a fluid compartment containing enzymes that drive carbon fixation. This contrast shows that stromal roles range from regulating tissue environments to supporting a specific biochemical process.
Altered stromal organization can modify cell signaling, nutrient delivery, mechanical support, and repair. These changes may influence inflammatory behavior and the way tumors progress through their surrounding environment. Because stromal elements interact with specialized cells, examining them can help researchers interpret disease behavior and understand why the local tissue context matters in cancer research.
Stromal analysis helps connect tissue architecture with cellular function. In histology, researchers can consider how supportive elements are arranged around specialized cells. In developmental biology, they can examine how that organization contributes to tissue formation and coordination. The resulting context can clarify how cellular environments shape physiology, regeneration, and changes associated with disease.
Therapeutic responses may depend not only on specialized cells but also on their surrounding environment. Stromal components can regulate signaling, nutrient delivery, inflammation, and repair, all of which influence tissue and disease behavior. Including stromal organization in cancer research therefore provides a broader basis for interpreting treatment responses and for relating cellular behavior to the tissue context.