Valvular Heart Disease

Valvular heart disease is a group of conditions in which one or more heart valves fail to open or close normally, disrupting the one-way flow of blood through the heart and circulatory system. Valve narrowing, or stenosis, obstructs forward flow, whereas incomplete closure, or regurgitation, allows blood to leak backward; both abnormalities can increase cardiac workload and alter pressure or volume in the chambers. In biology and medicine, studying these mechanisms helps explain symptoms such as breathlessness, fatigue, and reduced exercise tolerance, while supporting diagnosis, monitoring, and treatment through medications, valve repair, or replacement.

Valvular Heart Disease - Related Videos

Research

JoVE Journal - Biology

Isolation of Valvular Endothelial Cells

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Cited by 82 •

2010

We provide a method for isolating and culturing pure populations of heart valve endothelial cells (VEC). VEC can be isolated from either side of the cusp or leaflet and immediately following, underlying interstitial cell (VIC) isolation is straightforward.

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

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Cited by 15 •

2017

This protocol provides a detailed description of the echocardiographic approach for comprehensive phenotyping of heart and heart valve function in mice.

Research

JoVE Journal - Medicine
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Implantation of Total Artificial Heart in Congenital Heart Disease

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Cited by 40 •

2014

This is a case report of a patient with congenitally corrected transposition of the great arteries (CCTGA) who received a total artificial heart (TAH) as a bridge to heart transplant. The TAH was successfully implanted with modifications to accommodate the patient's congenitally malformed heart.

Isolation and Culture of Avian Embryonic Valvular Progenitor Cells

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Cited by 4 •

2010

This article will provide a method for isolating and culturing quail or chicken HH14- valve endocardial cells and HH25 valve cushion mesenchymal cells.

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model

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Cited by 12 •

2012

The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.

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