Villi
Villi - Related Videos
10:51
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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Cited by 68 •
2016
We describe an in vitro protocol to co-culture gut microbiome and intestinal villi for an extended period using a human gut-on-a-chip microphysiological system.
06:40
3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation
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Cited by 2 •
2021
The procedure describes isolation of the villi from the mouse intestinal epithelium undergoing dedifferentiation to determine their organoid forming potential.
01:33
Adult Stem Cells
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2019
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
05:47
Intravital Visualization of Gamma Delta Intraepithelial Lymphocytes
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2025
This video demonstrates the visualization of γδ intraepithelial lymphocytes (IELs) in transgenic mice using confocal microscopy. The surgical procedure involves creating a perforation line and making a longitudinal incision to expose the intestinal mucosa and villi. The transgenic mice express reporter proteins exclusively in γδ IELs, allowing their tracking. Intravital imaging captures the dynamic movement of green fluorescence-labeled γδ IELs along the intestinal epithelial cell's basement...
04:37
Intestinal Crypts Isolation: A Method to Isolate Whole Crypts from Small Intestine of Murine Model
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2023
In this video, we demonstrate a technique to isolate whole crypts from a mouse’s small intestine. The isolated whole crypts can be used to propagate long-lived and self-renewing 3D organoids in vitro.
FAQs
The epithelial covering provides the surface through which digested nutrients cross, while the internal blood capillaries and lacteal provide transport routes after crossing. This arrangement links the intestinal contents directly with both the circulatory and lymphatic systems, helping distribute absorbed materials beyond the digestive tract.
An expanded villus surface creates more contact between digested intestinal contents and absorptive epithelial cells. That increased contact allows the intestine to handle uptake more efficiently across the lining, supporting the movement of sugars, amino acids, fatty acids, vitamins, and minerals into the body's transport systems.
Blood capillaries and lacteals are distinct transport structures within each villus. Together, they provide routes for nutrients that cross the epithelial surface to enter either the circulation or the lymphatic system. Their presence makes the villus more than a surface projection by connecting absorption with distribution throughout the body.
Villus structure shows that digestion and absorption are closely connected but not identical processes. Digestion produces absorbable nutrients, while the epithelial surface and underlying transport vessels support their movement away from the intestinal contents. Studying these structures therefore helps explain how processed food materials become available to the body.
Damage to intestinal villi can interfere with the surface and transport arrangement needed for efficient nutrient uptake. Because villi support absorption of sugars, amino acids, fatty acids, vitamins, and minerals, their impairment may help explain malabsorption, a condition in which the intestine does not take up nutrients effectively.
Villus function supports the uptake of several major nutrient groups, including sugars, amino acids, fatty acids, vitamins, and minerals. Considering these groups together shows why villi are important in nutrition: their absorptive role affects both energy-related materials and substances needed for broader biological functions.