Nose-only Restrainer
Nose-only Restrainer - Related Videos
08:46
Nose, Sinuses, Oral Cavity and Pharynx Exam
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2023
Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA This video provides an overview of sinus, nose, and throat examinations. The demonstration begins with a brief overview of the anatomy of the region. The upper third of the nose is bony, and the bottom two-thirds are cartilaginous. Air entering the nares passes through the nasal vestibules and into the narrow passageway between the nasal septum...
11:02
Fruit Volatile Analysis Using an Electronic Nose
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Cited by 10 •
2012
A rapid method for volatile compound analysis in fruit is described. The volatile compounds present in the headspace of a homogenate of the sample are rapidly separated and detected with ultra-fast gas chromatography (GC) coupled with a surface acoustic wave (SAW) sensor. A procedure for data handling and analysis is also discussed.
07:28
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Cited by 11 •
2017
The inhalation unit described herein can generate, sample for characterization, and uniformly deposit a drug aerosol in the lungs of rodents. This enables the pre-clinical determination of the efficacy and safety of drug doses deposited in the lungs; key data enabling clinical inhaled drug development.
01:24
Nose and Nasal Cavity
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2025
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
11:08
Neuropharmacological Manipulation of Restrained and Free-flying Honey Bees, Apis mellifera
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Cited by 13 •
2016
This manuscript describes several protocols for administering pharmacological agents to honey bees, including simple noninvasive methods for free-flying bees, as well as more invasive variants that allow precise localized treatment of restrained bees.
FAQs
The individual restraint tube positions the animal consistently relative to the exposure system, allowing airborne material to reach the nasal opening under defined conditions. This arrangement helps investigators control exposure duration and the delivered test material more consistently across animals. Such standardization is important when comparing respiratory responses, disease progression, or treatment effects between experimental groups.
Restricting exposure to the nose reduces direct contact between the test material and the animal’s skin or fur. This separation helps distinguish effects associated with respiratory exposure from effects caused by external contamination. It also supports more controlled interpretation of dose-related findings when aerosols, gases, or infectious particles are evaluated in laboratory studies.
The material delivered, its airborne form, the exposure duration, and the defined conditions within the exposure system can all influence study outcomes. These variables determine how consistently animals receive the intended respiratory challenge. Maintaining comparable conditions is therefore important for interpreting immune responses, infection-related changes, toxicology findings, and differences in vaccine performance.
The basic setup includes an individual restraint tube and an exposure system connected to the tube. Depending on the study, the system delivers an aerosol, gas, or infectious particle preparation through the nasal opening. The equipment must support defined exposure conditions and a controlled duration so that respiratory studies can be compared across animals and experimental groups.
A study generally requires placing the animal in an individual restraint tube, connecting that tube to the exposure system, delivering the selected airborne substance through the nasal opening, and maintaining the defined exposure duration. Afterward, investigators can examine outcomes such as mucosal immune responses, respiratory infection effects, toxicology findings, or disease progression.
This approach is useful when investigators need controlled respiratory exposure for studies of respiratory pathogens, mucosal immune responses, vaccine performance, toxicology, or disease progression. By limiting contact with skin and fur while defining dose and duration, it helps relate observed outcomes more directly to material delivered through the respiratory route.