Chronic Pain Risk
Chronic Pain Risk - Related Videos
06:44
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
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Cited by 22 •
2009
A demonstration of the bedside test for cutaneous allodynia and its clinical implications.
02:20
Modulation of Chronic Pain Using Multicolumn Paddle Lead Spinal Cord Stimulation
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2025
Source: Remacle, T., et al. Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation. J. Vis. Exp. (2018)This video demonstrates the method of using multicolumn paddle lead spinal cord stimulation to manage chronic lower back pain in Failed back surgery syndrome (FBSS) patients. The pre-implanted lead delivers targeted electrical pulses that activate non-painful sensory pathways, interrupting pain signals and reducing pain perception.
08:23
Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
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Cited by 151 •
2012
Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal test).
10:52
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
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Cited by 45 •
2015
This manuscript describes a rodent model to study trigeminal neuropathic pain. The methods described include surgical procedures to perform a chronic constriction injury of the rat’s infraorbital nerve and the post-surgical behavioral tests to measure the changes in spontaneous and evoked behavior that are indicative of persistent pain and allodynia.
14:56
An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
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Cited by 107 •
2010
Diffuse noxious inhibitory control, temporal summation and wound hyperalgesia testing are demonstrated in the obstetric patient. These tests evaluate inhibitory and excitatory mechanisms of pain processing and are here utilized to evaluate endogenous analgesia at different time-points during pregnancy and the peripartum period to help reveal individual s risk for persistent pain.
FAQs
Ongoing nociceptive signaling can continue to influence pain processing after the original injury or disease has begun to resolve. When these signals persist, they may interact with nervous system sensitization, in which pain processing becomes more responsive. This interaction helps explain why some patients continue to experience pain or develop recurrent symptoms beyond expected tissue healing.
Nervous system sensitization can alter how pain signals are processed, making the relationship between tissue injury and experienced pain less direct. Its importance lies in showing that persistent pain may reflect changes in processing as well as the original condition. Recognizing this mechanism supports a broader assessment rather than focusing only on the injured tissue.
Psychological and social factors can modify pain processing and interact with biological contributors such as inflammation and sensitization. They therefore form part of the overall risk pattern rather than representing separate explanations for pain. Including these influences in clinical thinking can help clinicians choose more individualized rehabilitation, medication, and behavioral strategies for vulnerable patients.
Inflammation is one component of the interaction that shapes chronic pain risk. Along with the original disease or injury, ongoing nociceptive signaling, nervous system sensitization, and psychological or social influences, it can contribute to continued changes in pain processing. Considering these factors together gives clinicians a more complete basis for understanding why pain may persist or recur.
Assessment focuses on identifying patients whose combined biological, psychological, and social circumstances may increase vulnerability to persistent or recurrent pain. Clinicians consider the original injury or disease alongside signaling, sensitization, inflammation, and factors that alter pain processing. The resulting risk information can guide earlier intervention and help tailor care instead of relying on a uniform plan.
Risk information can guide decisions when clinicians are planning rehabilitation, medication, or behavioral strategies for patients who may be vulnerable to long-term pain. It supports earlier and more individualized intervention, with the selected approach matched to the factors influencing that patient’s pain processing. This use connects prediction with practical patient care rather than treating risk assessment as an isolated measurement.
Earlier identification may help reduce long-term disability and improve quality of life by directing attention toward patients who need timely, tailored support. Risk prediction can also encourage more precise approaches to pain prevention and treatment. Its value is therefore measured not only by recognizing vulnerability, but by using that information to shape care before pain becomes more persistent.