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Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
 

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Article doi: 10.3791/3393
March 13th, 2012

Summary March 13th, 2012

Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal test).

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