Elderly Diabetes
Elderly Diabetes - Related Videos
10:43
Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
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Cited by 98 •
2007
Our protocol was developed to cleanly and easily deliver islets or cells under the kidney capsule of mice. Cells are concentrated into pellets in the final tubing used for transplanting the cells under the kidney capsule. The ease of this technique reduces stress to the cells and the mouse.
16:26
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Cited by 2 •
2007
16:59
Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
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Cited by 5 •
2012
We describe hepatic neo-islet formation in STZ (streptozotocin)-induced diabetic mice by gene transfer of Neurogenin3 (Ngn3) and Betacellulin (Btc) using helper-dependent adenoviral vector (HDAd) and the reversal of hyperglycemia. Our method takes advantages of helper-dependent adenoviral vectors with their highly efficient in vivo transduction and the long lasting gene expression.
10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Cited by 69 •
2013
Metabolic memory is the phenomenon by which diabetic complications persist and progress unimpeded even after euglycemia is achieved pharmaceutically. Here we describe a diabetes mellitus zebrafish model which is unique in that it allows for the examination of the mitotically transmissible epigenetic components of metabolic memory in vivo.
12:59
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Cited by 6 •
2017
The effect of short-term resistance training on elderly people was investigated through the simultaneous use of several methods. Compared to a control group, many improvements were seen, including on muscle aerobic capacity, glucose tolerance, strength, power, and muscle quality (i.e., protein involved in cell signaling and muscle fiber type composition).
FAQs
Aging can worsen glucose regulation through increasing insulin resistance and a progressive decline in pancreatic beta-cell function. Reduced activity, medication effects, and acute illness may add further disruption, making glucose levels less stable. These interacting factors explain why clinicians assess the older adult’s overall medical and functional situation rather than relying on glucose control alone.
Individualized targets account for differences in multimorbidity, functional capacity, cognitive status, and vulnerability to hypoglycemia. A target that is appropriate for one older adult may not suit another whose health conditions or daily abilities create different treatment risks. This approach supports safer management while keeping treatment aligned with the person’s overall health and quality of life.
Acute illness can destabilize glucose regulation, while some medications and reduced physical activity may contribute to worsening hyperglycemia or broader treatment challenges. Because these influences can change over time, clinicians need to reassess control and treatment choices when an older adult becomes ill, changes medication, or experiences a decline in usual activity.
Medication review helps clinicians examine whether the current treatment remains appropriate for an older adult’s changing health status, functional abilities, and risks. It is particularly relevant when multimorbidity, acute illness, or possible hypoglycemia complicates management. Reviewing treatment alongside glucose monitoring can support safer choices and reduce the chance that therapy undermines independence or quality of life.
Nutrition and physical activity form part of an individualized management plan rather than serving as isolated recommendations. Their role should be considered alongside age-related changes, functional capacity, current treatment, and other medical conditions. Addressing these areas can help support glucose management while keeping care focused on daily function, independence, and quality of life.
Monitoring should include hypoglycemia as well as cardiovascular disease, kidney disease, and neuropathy. Clinicians should also remain attentive to cognitive and functional impairment because these problems can affect treatment safety and daily self-management. Evaluating these outcomes together provides a broader picture of whether care is protecting health, preserving independence, and maintaining quality of life.