Epithelial Disruption
Epithelial Disruption - Related Videos
11:49
Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
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Cited by 5 •
2014
Human infection by Entamoeba histolytica leads to amoebiasis, a major cause of diarrhea in tropical countries. Infection is initiated by pathogen interactions with intestinal epithelial cells, provoking the opening of cell-cell contacts and consequently diarrhea, sometimes followed by liver infection. This article provides a model to assess the early host-pathogen interactions to improve our understanding of amoebiasis pathogenesis.
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Single Photon Emission Computed Tomography for Assessing Brain Function Disruption
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2025
A traumatic brain injury, or TBI, impairs blood flow to the impacted regions and disrupts the activity of dopaminergic neurons.To investigate TBI-associated disruptions, begin by intravenously injecting a lipophilic radioactive tracer into a patient.The tracer travels through the cerebral vessels and diffuses into cells of the cortical and subcortical brain tissue.Perform single photon emission computed tomography, or SPECT, to detect the tracer-emitted radiation. The resulting signal intensity...
09:43
Methods to Test Endocrine Disruption in Drosophila melanogaster
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Cited by 8 •
2019
Endocrine disruptor chemicals (EDCs) represent a serious problem for organisms and for natural environments. Drosophila melanogaster represents an ideal model to study EDC effects in vivo. Here, we present methods to investigate endocrine disruption in Drosophila, addressing EDC effects on fecundity, fertility, developmental timing, and lifespan of the fly.
08:51
Mammary Epithelial Transplant Procedure
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Cited by 23 •
2010
This article demonstrates the procedure developed by DeOme KB et al. (1959) and the sparing procedure developed by Brill B et al. (2008) for clearing the 4th inguinal mammary fat pad of a pubescent mouse in preparation for transplantation of mammary fragments, mammary epithelial cells, or mammary tumor cells.
10:09
Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
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Tissue-specific analysis of a hair follicle regeneration model using lentivirus to mediate gain- or loss-of-function.
FAQs
Cell-cell junctions normally help maintain continuity between neighboring epithelial cells. When injury or inflammation weakens these connections, substances can pass more readily through the space between cells, known as the paracellular route. This increased permeability may expose underlying tissue to fluids, microbes, or inflammatory signals, linking structural damage with disturbed organ function.
Increased paracellular permeability indicates that the barrier is allowing greater passage between epithelial cells than it should. That change can permit fluids, microbes, and inflammatory signals to reach underlying tissues. Its importance depends on the affected organ, because barrier failure can contribute to infection, chronic inflammation, or impaired surface protection in different medical settings.
Restoration depends on repairing damaged epithelial cells and re-establishing the connections that maintain a continuous surface. Studying these processes helps explain how tissues recover after injury and how persistent inflammation or infection may interfere with recovery. In medicine, this repair perspective supports efforts to develop treatments that promote healing or protect vulnerable tissue surfaces.
These stressors can produce related barrier problems through different initiating events. Injury may directly damage epithelial cells, whereas infection can challenge the surface with microbes, and inflammation can weaken junctions or alter epithelial behavior. Examining the initiating stressor alongside barrier integrity helps researchers interpret why permeability changes occur and how organ function may be affected.
Assessment focuses on whether epithelial continuity and barrier function have been maintained or lost. Researchers can examine changes in permeability and the condition of epithelial cells or their junctions, then relate those findings to inflammation, infection, or tissue injury. Such evaluations help characterize disease processes, monitor restoration, and compare strategies intended to protect the barrier.
This topic is particularly relevant to wound healing, intestinal and airway diseases, infection, and chronic inflammation. In each setting, altered epithelial integrity can affect exposure of underlying tissue and normal organ function. Studying the barrier provides a way to connect local surface damage with broader disease mechanisms and to identify opportunities for diagnosis or treatment development.
Research can connect measurable barrier changes with the processes that restore epithelial continuity. That information may help identify strategies designed to reduce barrier damage, support healing, or protect tissue surfaces from further stress. It also provides a framework for evaluating whether a potential intervention improves barrier function rather than addressing inflammation or infection without restoring epithelial protection.