Rabbit Atherosclerosis Model
Rabbit Atherosclerosis Model - Related Videos
09:14
The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
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Cited by 16 •
2017
Animal models of atherosclerosis are essential to understand the mechanism and to investigate newer approaches to prevent plaque development or rupture, a leading cause of death in the industrialized world. This protocol uses a combination of balloon injury and cholesterol rich diet to induce atherosclerotic plaques in rabbit iliac artery.
08:34
Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models
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Cited by 8 •
2014
This video shows two models of intimal plaque development in murine arteries and emphasizes the differences in myointimal hyperplasia and atherosclerosis.
01:36
Anesthesia and Monitoring in a Rabbit Model
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2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Anesthesia is an essential component of rabbit surgical and experimental procedures because it prevents pain, reduces stress responses, and helps immobilize the animal during handling and manipulation when general anesthesia is...
02:24
Tracheal Cannulation in Rabbit Model: A Procedure to Insert Tracheal Cannula into the Rabbit Trachea
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2025
This video demonstrates the surgical creation of an opening in the rabbit trachea to insert a tracheal cannula for artificially ventilating the lungs.
09:43
In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Cited by 32 •
2011
We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy...
FAQs
The model can separate dietary and mechanical contributions to arterial disease. A cholesterol-rich diet increases lipid exposure, whereas arterial injury adds damage to the vessel lining; combining them may produce complementary effects. Comparing these conditions helps determine whether an observed change reflects altered lipid handling, endothelial dysfunction, or their combined influence on subsequent plaque development.
Plaque development is studied as a connected sequence rather than a single endpoint. Lipid accumulation occurs alongside endothelial dysfunction and inflammation, and these changes accompany lesion formation in the vessel wall. Examining their relationship helps investigators connect metabolic and vascular disturbances with visible arterial pathology and assess whether an intervention alters disease progression.
Changes in lipoprotein metabolism provide a measurable link between dietary exposure and arterial pathology. Investigators can relate altered lipid handling to plaque growth, composition, and stability. This relationship allows the model to test whether a preventive strategy or drug affects only the amount of plaque or also the characteristics that determine its stability.
A typical study begins with a cholesterol-rich diet, with arterial injury added in some experimental designs. Researchers then evaluate changes in lipoprotein metabolism and arterial pathology, using outcomes such as plaque growth, composition, or stability and, where relevant, imaging. This workflow supports comparisons among dietary conditions, interventions, and experimental groups.
The model provides a setting for investigating methods that assess atherosclerotic lesions and their development. Researchers can examine whether an imaging approach captures changes in plaque growth, composition, or stability and relate those findings to arterial pathology. Such evaluations help refine cardiovascular imaging strategies before they proceed to clinical studies.
Preventive strategies and pharmacological interventions can be assessed by examining their effects on plaque growth, composition, and stability. Researchers may also evaluate how treatments influence the underlying changes in lipoprotein metabolism, endothelial dysfunction, or inflammation. These outcomes distinguish effects on overall disease burden from effects on specific plaque characteristics relevant to cardiovascular research.
Within medicine, the model connects mechanistic investigations with preclinical evaluation. It links lipoprotein metabolism, endothelial dysfunction, inflammation, and arterial pathology to measurable plaque outcomes. Findings can help researchers select imaging methods, dietary strategies, or candidate therapies for further evaluation before clinical studies, while maintaining focus on cardiovascular disease mechanisms and plaque behavior.