Regional Lung Function
Regional Lung Function - Related Videos
11:39
Identification of Functional Protein Regions Through Chimeric Protein Construction
0 Views •
2019
Structurally related proteins frequently exert distinct biological functions. The exchange of equivalent regions of these proteins in order to create chimeric proteins constitutes an innovative approach to identify critical protein regions that are responsible for their functional divergence.
05:25
Dissection and Isolation of Region-Specific Decellularized Lung Tissue
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2023
Presented here is a protocol for the isolation of regional decellularized lung tissue. This protocol provides a powerful tool for studying complexities in the extracellular matrix and cell-matrix interactions.
07:45
Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
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2025
This protocol provides instructions for intranasal administration of IAV and downstream analysis of mouse lung damage and associated transcriptional changes to lung cell types.
11:31
Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks
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Cited by 16 •
2014
Monitoring brain activity during upright motor tasks is of great value when investigating the neural source of movement disorders. Here, we demonstrate a protocol that combines functional near infrared spectroscopy with continuous monitoring of muscle and kinematic activity during 4 types of motor tasks.
10:44
Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
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Cited by 4 •
2024
Three-dimensional (3D) phase-resolved functional lung (PREFUL) is a functional magnetic resonance imaging (MRI) technique that allows for quantification of regional ventilation of the whole human lung volume, using tidal breathing and contrast-agent free acquisition for 8 min. Here, we present an MR protocol to collect and analyze 3D PREFUL imaging data.
FAQs
Gravity contributes to differences in ventilation and perfusion between lung regions. Its effects interact with airway and vascular anatomy and with the mechanical behavior of lung tissue, so air and blood may not be distributed uniformly. Assessing these regional patterns helps reveal whether functional variation reflects normal physical influences or changes associated with disease.
Ventilation describes regional airflow, whereas perfusion describes regional blood flow, and gas exchange depends on their interaction. Examining these components together can show whether a lung area receives air, blood, or both unevenly. This combined perspective provides more information about regional function than considering airflow or blood flow in isolation.
Disease can change regional lung function by altering airflow, blood flow, or the properties of lung tissue. These changes may create areas with uneven ventilation, perfusion defects, or poorly functioning tissue. The resulting spatial pattern can help distinguish abnormal regions from better-functioning areas and can support evaluation of conditions such as asthma, chronic obstructive pulmonary disease, and respiratory failure.
Whole-lung measurements can summarize overall performance but may not show where dysfunction occurs. Regional assessment identifies the location and distribution of uneven ventilation, perfusion defects, and poorly functioning tissue. This added spatial information can clarify how disease affects the lungs and support more targeted diagnosis, treatment planning, and monitoring.
Regional Lung Function can be assessed with computed tomography, magnetic resonance imaging, nuclear medicine scans, or electrical impedance tomography. These approaches provide ways to examine differences across lung areas rather than relying solely on an overall organ-level assessment. The resulting regional information can be used to identify abnormal ventilation, perfusion, or tissue function.
Clinicians use regional findings to identify uneven ventilation, perfusion defects, and poorly functioning tissue. Those observations can contribute to diagnosis, help inform treatment planning, and support monitoring over time. The approach is relevant when evaluating asthma, chronic obstructive pulmonary disease, pulmonary embolism, or respiratory failure, where disease-related regional changes may be clinically important.
Regional assessment is relevant because pulmonary embolism and respiratory failure can involve abnormal distributions of lung function. Mapping regional ventilation, perfusion, and gas exchange may reveal affected or poorly functioning areas that an overall measurement could obscure. This information supports clinical evaluation and can help track regional changes during ongoing management.