Functional Topography

Functional topography is the spatial organization of neural functions across the brain, describing how particular regions or cortical locations contribute to sensory, motor, cognitive, and behavioral processes. In neuroscience, researchers map this organization by measuring activity with methods such as functional magnetic resonance imaging, electrophysiology, or neural stimulation while participants or animals perform controlled tasks; patterns of activity reveal functional representations and their connections. Functional topography supports the study of sensory and motor maps, brain networks, development, and plasticity. It also guides interpretation of neurological disorders, surgical planning, and interventions that depend on accurately identifying functionally specialized brain regions.

Functional Topography - Related Videos

Education

JoVE Core - Civil Engineering

Methods of Obtaining Topography

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2025

Topography involves measuring and mapping land elevations, natural features, and artificial structures to create accurate representations of the terrain. Topographic surveying relies on traditional and modern methods, each with distinct advantages and limitations.Traditional Surveying Methods:Transit stadia surveys and plane table surveys were widely used traditional surveying methods. These techniques relied on instruments like theodolites and stadia rods for measuring distances and angles,...

Research

JoVE Journal - Engineering
Free Sample

Laser Micromachining for Polymer Surface Topography Design

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2025

A method for imposing surface topography of light-absorbing composite polymer materials, particularly magnetoactive elastomers (MAEs), by using laser micromachining is presented. This method enables large flexibility in topographical designs and rapid prototyping. An example of structuring MAE surfaces, characterization, and their response to the external magnetic field is demonstrated.

Revealing Neural Circuit Topography in Multi-Color

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Cited by 6 •

2011

We provide a practical guide for delivering tracers in vivo and use the spinocerebellar pathway as a model system to demonstrate essential steps for successful neuronal circuit analysis in mice. We describe in detail our versatile tracing protocol that exploits wheat germ agglutinin (WGA) conjugated to Alexa fluorophores.

Wholemount Immunohistochemistry for Revealing Complex Brain Topography

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Cited by 17 •

2012

Neural circuits are topographically organized into functional compartments with specific molecular profiles. Here, we provide the practical and technical steps for revealing global brain topography using a versatile wholemount immunohistochemical staining approach. We demonstrate the utility of the method using the well-understood cytoarchitecture and circuitry of cerebellum.

Enabling Real-Time Compensation in Fast Photochemical Oxidations of Proteins for the Determination of Protein Topography Changes

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Cited by 8 •

2020

Fast photochemical oxidation of proteins is an emerging technique for the structural characterization of proteins. Different solvent additives and ligands have varied hydroxyl radical scavenging properties. To compare the protein structure in different conditions, real-time compensation of hydroxyl radicals generated in the reaction is required to normalize reaction conditions.

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