Mri Protocol
Mri Protocol - Related Videos
10:26
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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Cited by 5 •
2015
The goal of this study is to use magnetic resonance venography with long-circulating gadolinium-based contrast agent and direct thrombus imaging for quantitative evaluation of DVT volume in a multicenter, clinical trial setting. Inter- and intra-observer variability assessments were conducted, and reproducibility of the protocol was determined.
08:57
Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
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2021
We provided a detailed protocol for a standardized method of optic nerve assessment and quantification using MRI, utilizing a widely available imaging sequence, and open access software for image analysis. Following this standardized protocol would provide meaningful data for comparison between different patients and different studies.
15:53
Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning
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Cited by 30 •
2016
The overall goal of this protocol is to accurately align magnetic resonance imaging (MRI) image volumes with histology sections via the creation of customized 3D-printed brain holders and slicer boxes.
06:06
Optogenetic Functional MRI
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Cited by 18 •
2016
This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.
08:19
Protocol for the Evaluation of MRI Artifacts Caused by Metal Implants to Assess the Suitability of Implants and the Vulnerability of Pulse Sequences
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Cited by 11 •
2018
We describe a standardized method to evaluate magnetic resonance imaging artifacts caused by implants to estimate the suitability of the implants for magnetic resonance imaging and/or the vulnerability of different pulse sequences to metallic artifacts simultaneously.
FAQs
Sequence selection determines which tissue property or physiological signal becomes most informative. Structural sequences emphasize brain anatomy, diffusion sequences characterize white-matter organization, susceptibility sequences capture vascular features, and functional sequences measure blood-oxygen-level changes. The chosen combination therefore links the imaging protocol to the research question, rather than treating every scan as interchangeable.
Image contrast depends on how radiofrequency pulses, magnetic-field gradients, and acquisition parameters interact with hydrogen-nucleus signals. Differences in relaxation and other tissue properties then produce separable signal patterns. Positioning also matters because a standardized orientation helps preserve comparability across participants. Adjusting these elements can change which anatomical or functional differences are visible in the resulting images.
These sequence families answer different neuroscience questions rather than providing interchangeable views. Structural imaging focuses on anatomy, diffusion imaging on white-matter organization, susceptibility imaging on vascular features, and functional imaging on blood-oxygen-level changes. Using one or several depends on the target measurement. This distinction helps researchers match observed image patterns to the biological feature under study.
A planning workflow starts by defining the measurement of interest, then selecting the sequence family or combination that can provide it. Researchers specify imaging parameters and participant positioning while keeping those choices consistent across scans. This standardization is especially important for studies comparing participants, because differences in acquisition choices could complicate interpretation of anatomical, connectivity, or functional findings.
In neuroscience, an MRI protocol can be tailored to studies of brain structure, connectivity, development, neurological disease, or treatment response. Structural and diffusion choices support anatomy and white-matter questions, whereas functional or susceptibility choices address blood-oxygen-level changes or vascular features. The protocol should therefore reflect whether the study seeks anatomical, organizational, functional, or vascular information.
Consistent protocols improve image quality and make measurements more comparable across participants. That matters when a study examines group differences, developmental patterns, disease-related changes, or responses to treatment, because the same acquisition framework supports more direct comparison. The resulting images can contribute evidence about brain anatomy, white-matter organization, connectivity, blood-oxygen-level changes, and vascular features.