Sleep Spindles

Sleep spindles are brief bursts of rhythmic brain activity that occur during non-rapid eye movement (NREM) sleep, especially stage 2, and serve as important markers of sleep organization. They arise from interactions between the thalamus and cerebral cortex, producing waxing-and-waning oscillations typically in the 11–16 Hz range that help regulate the flow of sensory information to the cortex. In psychology and neuroscience, spindle density, timing, and frequency are studied in relation to memory consolidation, learning, sleep stability, and individual differences. Electroencephalography (EEG) measurements of sleep spindles also support research on aging, psychiatric conditions, and sleep disorders.

Sleep Spindles - Related Videos

Research

JoVE Journal - Neuroscience

High-Definition Transcranial Direct Current Stimulation During Sleep

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2025

This protocol describes high-definition transcranial direct current stimulation during sleep with simultaneous electroencephalography monitoring to investigate causal relationships between targeted brain regions and sleep as well as its related processes.

Polygraphic Recording Procedure for Measuring Sleep in Mice

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Cited by 55 •

2016

The recording of electroencephalogram (EEG) and electromyogram (EMG) in freely behaving mice is a critical step to correlate behavior and physiology with sleep and wakefulness. The experimental protocol described herein provides a cable-based system for acquiring EEG and EMG recordings in mice.

Quantitative Measurement of the Immune Response and Sleep in Drosophila

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Cited by 17 •

2012

To understand a link between the immune response and behavior, we describe a method to measure locomotor behavior in Drosophila during bacterial infection as well as the ability of flies to mount an immune response by monitoring survival, bacterial load, and real-time activity of a key regulator of innate immunity, NFκB.

Education

JoVE Core - Molecular Biology

The Mitotic Spindle

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2021

The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei. The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...

Spindle Assembly

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2021

Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus. In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...

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