Jianglin Fan

Department of Molecular Pathology, University of Yamanashi

Affiliated withUniversity of Yamanashi Wuyi University Wuyi University

Research Area

Biography

Jianglin Fan is Professor and Chairman of Molecular Pathology at University of Yamanashi School of Medicine, Yamanashi, Japan. He received his MD degree at Yanbian University School of Medicine, China and Ph.D. degree at Saga University, Japan. He got his postdoctoral training at Gladstone Institute, University of California, San Francisco. Dr. Fan has been working on atherosclerosis for more than 30 years and his research interests include elucidation of the molecular mechanisms of atherosclerosis, lipid and lipoprotein metabolism, and inflammation. One of his major achievements was to develop novel transgenic and knockout rabbit models for the study of cardiovascular disease. His work has led to more than 180 publications in prestigious peer-review journals.

JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 32	2013
Publication title Cited by 9	2021
Publication title	2026

Other Publications

Article	Year
Lipoprotein(a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo(a) transgenic rabbits. The American journal of pathology\| PubMed ID: 11786416	2002
Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a). The Journal of biological chemistry\| PubMed ID: 12196525	2002
A rapid PCR method of genotyping LDL receptor mutations in WHHL rabbits. Journal of atherosclerosis and thrombosis\| PubMed ID: 12226556	2002
Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles. Muscle & nerve\| PubMed ID: 12451608	2002
Accelerated atherosclerosis with apolipoprotein(a) and oxidized low-density lipoprotein deposition in acute rejection of transplanted kidney: analogous to atherosclerosis. Clinical transplantation\| PubMed ID: 12464130	2002
Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 12622720	2003
Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit). Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 12738683	2003
Inflammatory reactions in the pathogenesis of atherosclerosis. Journal of atherosclerosis and thrombosis\| PubMed ID: 12740479	2003
Transgenic rabbits as therapeutic protein bioreactors and human disease models. Pharmacology & therapeutics\| PubMed ID: 12951161	2003
Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity. The Journal of biological chemistry\| PubMed ID: 14660566	2004
NO-1886 inhibits size of adipocytes, suppresses plasma levels of tumor necrosis factor-alpha and free fatty acids, improves glucose metabolism in high-fat/high-sucrose-fed miniature pigs. Pharmacological research : the official journal of the Italian Pharmacological Society\| PubMed ID: 14726214	2004
Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 15122303	2004
A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis. International journal of experimental pathology\| PubMed ID: 15312127	2004
Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit). Journal of atherosclerosis and thrombosis\| PubMed ID: 15356377	2004
Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits. Transgenic research\| PubMed ID: 15359603	2004
Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits. The American journal of pathology\| PubMed ID: 15466401	2004
Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis. Arthritis and rheumatism\| PubMed ID: 15476203	2004
High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits. Metabolism: clinical and experimental\| PubMed ID: 15562391	2005
Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase. Cardiovascular research\| PubMed ID: 15639492	2005
Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits. Atherosclerosis\| PubMed ID: 15721013	2005
Establishment of a SPF colony of human apo(a) transgenic rabbits by frozen-thawed embryo transfer. Experimental animals / Japanese Association for Laboratory Animal Science\| PubMed ID: 16093649	2005
Localized vessel expression of lipoprotein lipase in rabbits leads to rapid lipid deposition in the balloon-injured arterial wall. Atherosclerosis\| PubMed ID: 16191430	2006
C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance. The American journal of pathology\| PubMed ID: 16192648	2005
Transgenic rabbits with increased VEGF expression develop hemangiomas in the liver: a new model for Kasabach-Merritt syndrome. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 16200077	2005
Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits. Circulation\| PubMed ID: 16636188	2006
Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 17038632	2007
Lp(a) enhances coronary atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits. Atherosclerosis\| PubMed ID: 17045271	2007
Re-establishment of complement C6-deficient rabbit colony by cryopreserved sperm transported from abroad. Experimental animals / Japanese Association for Laboratory Animal Science\| PubMed ID: 17460363	2007
Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions. Journal of the American Society of Nephrology : JASN\| PubMed ID: 17554151	2007
Increased expression of human macrophage metalloelastase (MMP-12) is associated with the invasion of endometrial adenocarcinoma. Pathology, research and practice\| PubMed ID: 17574772	2007
Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet. Circulation research\| PubMed ID: 18032735	2008
Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits. The American journal of pathology\| PubMed ID: 18403602	2008
The effects of rosiglitazone on aortic atherosclerosis of cholesterol-fed rabbits. Thrombosis research\| PubMed ID: 18561986	2008
Endotoxin accelerates atherosclerosis independent of complement activation. Thrombosis research\| PubMed ID: 18692867	2009
Temporal and quantitative analysis of expression of metalloproteinases (MMPs) and their endogenous inhibitors in atherosclerotic lesions. Histology and histopathology\| PubMed ID: 18830936	2008
Unstable coronary plaques and cardiac events in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits: questions and quandaries. Current opinion in lipidology\| PubMed ID: 18957890	2008
Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19778946	2009
Human C-reactive protein does not promote atherosclerosis in transgenic rabbits. Circulation\| PubMed ID: 19901190	2009
Expression of CXCR4 and its ligand SDF-1 in intestinal-type gastric cancer is associated with lymph node and liver metastasis. Anticancer research\| PubMed ID: 20032431	2009
High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits. Atherosclerosis\| PubMed ID: 20832799	2010
Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII. Transgenic research\| PubMed ID: 21120692	2011
Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome. Hypertension\| PubMed ID: 21357282	2011
Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma). Aquatic toxicology (Amsterdam, Netherlands)\| PubMed ID: 21684243	2011
C-reactive protein is associated with the progression of acute embolic stroke in rabbit model. Journal of thrombosis and thrombolysis\| PubMed ID: 21874402	2012
Endothelial lipase mediates HDL levels in normal and hyperlipidemic rabbits. Journal of atherosclerosis and thrombosis\| PubMed ID: 22240910	2012
Expression of TRPV1 in rabbits and consuming hot pepper affects its body weight. Molecular biology reports\| PubMed ID: 22327653	2012
High-dose rosiglitazone is pro-atherogenic in cholesterol-fed rabbits. Atherosclerosis\| PubMed ID: 22377393	2012
Temporal and quantitative analysis of atherosclerotic lesions in diet-induced hypercholesterolemic rabbits. Journal of biomedicine & biotechnology\| PubMed ID: 22505812	2012
Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo. Inflammation\| PubMed ID: 22527144	2012
Protective effects of 20(s)-protopanaxtriol on viral myocarditis infected by coxsackievirus B3. Pathobiology : journal of immunopathology, molecular and cellular biology\| PubMed ID: 22688124	2012
Characteristics of Himalayan marmots and their response to an atherogenic diet. Experimental animals / Japanese Association for Laboratory Animal Science\| PubMed ID: 22850646	2012
Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23241412	2013
Expression systems and species used for transgenic animal bioreactors. BioMed research international\| PubMed ID: 23586046	2013
Comparative analyses of lipoprotein lipase, hepatic lipase, and endothelial lipase, and their binding properties with known inhibitors. PloS one\| PubMed ID: 23991054	2013
Probucol and cilostazol exert a combinatorial anti-atherogenic effect in cholesterol-fed rabbits. Thrombosis research\| PubMed ID: 24090606	2013
Probucol inhibits the initiation of atherosclerosis in cholesterol-fed rabbits. Lipids in health and disease\| PubMed ID: 24188322	2013
Effective gene targeting in rabbits using RNA-guided Cas9 nucleases. Journal of molecular cell biology\| PubMed ID: 24403564	2014
Ubiquitin-proteasome-dependent slingshot 1 downregulation in neuronal cells inactivates cofilin to facilitate HSV-1 replication. Virology\| PubMed ID: 24418541	2014
Epidermal growth factor receptor-PI3K signaling controls cofilin activity to facilitate herpes simplex virus 1 entry into neuronal cells. mBio\| PubMed ID: 24425731	2014
Probucol suppresses macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits. Journal of atherosclerosis and thrombosis\| PubMed ID: 24584175	2014
Urotensin II promotes atherosclerosis in cholesterol-fed rabbits. PloS one\| PubMed ID: 24747943	2014
Effects of cholesterol-loaded cyclodextrins on the rate and the quality of motility in frozen and thawed rabbit sperm. Experimental animals\| PubMed ID: 24770640	2014
Silencing herpes simplex virus type 1 capsid protein encoding genes by siRNA: a promising antiviral therapeutic approach. PloS one\| PubMed ID: 24794394	2014
Effects of type III antifreeze protein on sperm and embryo cryopreservation in rabbit. Cryobiology\| PubMed ID: 24809634	2014
Animal models of C-reactive protein. Mediators of inflammation\| PubMed ID: 24872599	2014
Effects of antisense oligonucleotides against C-reactive protein on the development of atherosclerosis in WHHL rabbits. Mediators of inflammation\| PubMed ID: 24872601	2014
C-reactive protein and arteriosclerosis. Mediators of inflammation\| PubMed ID: 24976688	2014
Demonstration of an add-on effect of probucol and cilostazol on the statin-induced anti-atherogenic effects. Histology and histopathology\| PubMed ID: 25078428	2014
Homocysteine reduces protein S-nitrosylation in endothelium. International journal of molecular medicine\| PubMed ID: 25189662	2014
Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine. Pharmacology & therapeutics\| PubMed ID: 25277507	2015
Bisphenol A exposure enhances atherosclerosis in WHHL rabbits. PloS one\| PubMed ID: 25333893	2014
Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits. Journal of applied toxicology : JAT\| PubMed ID: 25619500	2015
Carbonate ion-enriched hot spring water promotes skin wound healing in nude rats. PloS one\| PubMed ID: 25671581	2015
Production of Cloned Miniature Pigs Expressing High Levels of Human Apolipoprotein(a) in Plasma. PloS one\| PubMed ID: 26147378	2015
Motility and fertility of rabbit sperm cryopreserved using soybean lecithin as an alternative to egg yolk. Theriogenology\| PubMed ID: 26208436	2015
Combined use of probucol and cilostazol with atorvastatin attenuates atherosclerosis in moderately hypercholesterolemic rabbits. Lipids in health and disease\| PubMed ID: 26220196	2015
Practical assessment of the quantification of atherosclerotic lesions in apoE⁻/⁻ mice. Molecular medicine reports\| PubMed ID: 26239265	2015
High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Nutrition & metabolism\| PubMed ID: 26265929	2015
Production of human apolipoprotein(a) transgenic NIBS miniature pigs by somatic cell nuclear transfer. Experimental animals\| PubMed ID: 26411321	2016
Autocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits. BioMed research international\| PubMed ID: 26640798	2015
ApoE knockout rabbits: A novel model for the study of human hyperlipidemia. Atherosclerosis\| PubMed ID: 26724529	2016
AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis. Scientific reports\| PubMed ID: 26806558	2016
Dietary Cocoa Powder Improves Hyperlipidemia and Reduces Atherosclerosis in apoE Deficient Mice through the Inhibition of Hepatic Endoplasmic Reticulum Stress. Mediators of inflammation\| PubMed ID: 26980943	2016
Angiotensin II Destabilizes Coronary Plaques in Watanabe Heritable Hyperlipidemic Rabbits. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26988589	2016
Plasma High-Mannose and Complex/Hybrid N-Glycans Are Associated with Hypercholesterolemia in Humans and Rabbits. PloS one\| PubMed ID: 26999365	2016
Hyperlipidemia-associated gene variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models. Scientific reports\| PubMed ID: 27245873	2016
Hydrogen sulfide inhibits development of atherosclerosis through up-regulating protein S-nitrosylation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 27427853	2016
Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice. PloS one\| PubMed ID: 27564380	2016
Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-induced Cell Responses during Atherosclerosis in Apolipoprotein E-deficient Mice. Scientific reports\| PubMed ID: 27845432	2016
Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction. Journal of cellular and molecular medicine\| PubMed ID: 28244642	2017
Glutathione inhibits antibody and complement-mediated immunologic cell injury via multiple mechanisms. Redox biology\| PubMed ID: 28390315	2017
Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28428219	2017
Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2-Mediated Degradation of p53. Stem cells (Dayton, Ohio)\| PubMed ID: 28436570	2017
Increased Hepatic Expression of Endothelial Lipase Inhibits Cholesterol Diet-Induced Hypercholesterolemia and Atherosclerosis in Transgenic Rabbits. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28546217	2017
Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28642237	2017
Comparative studies of three cholesteryl ester transfer proteins and their interactions with known inhibitors. PloS one\| PubMed ID: 28767652	2017
Principles and Applications of Rabbit Models for Atherosclerosis Research. Journal of atherosclerosis and thrombosis\| PubMed ID: 29046488	2018
Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits. Mediators of inflammation\| PubMed ID: 29317793	2017
Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function. Cell death & disease\| PubMed ID: 29415989	2018
Transcriptomic analysis of the liver of cholesterol-fed rabbits reveals altered hepatic lipid metabolism and inflammatory response. Scientific reports\| PubMed ID: 29692426	2018
Differential Patterns of Secreted Frizzled-Related Protein 4 (SFRP4) in Adipocyte Differentiation: Adipose Depot Specificity. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 29730658	2018
Corrigendum to "Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits". Mediators of inflammation\| PubMed ID: 29849198	2018
Establishment of a novel non‑alcoholic fatty liver disease model using cholesterol‑fed rabbits with reference to the potential role of endoplasmic reticulum stress. Molecular medicine reports\| PubMed ID: 30015906	2018
Western diet feeding influences gut microbiota profiles in apoE knockout mice. Lipids in health and disease\| PubMed ID: 30021609	2018
Extracellular vesicles derived from donor oviduct fluid improved birth rates after embryo transfer in mice. Reproduction, fertility, and development\| PubMed ID: 30196804	2019
Treatment of atherosclerosis by traditional Chinese medicine: Questions and quandaries. Atherosclerosis\| PubMed ID: 30212682	2018
Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7. EBioMedicine\| PubMed ID: 30243490	2018
Hypertension Enhances Advanced Atherosclerosis and Induces Cardiac Death in Watanabe Heritable Hyperlipidemic Rabbits. The American journal of pathology\| PubMed ID: 30248339	2018
Salusin-α Inhibits Proliferation and Migration of Vascular Smooth Muscle Cell via Akt/mTOR Signaling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 30384378	2018
Genomic and Transcriptomic Analysis of Hypercholesterolemic Rabbits: Progress and Perspectives. International journal of molecular sciences\| PubMed ID: 30413026	2018
Hypoxic and Cold Adaptation Insights from the Himalayan Marmot Genome. iScience\| PubMed ID: 30581096	2019
Detection of potential new biomarkers of atherosclerosis by probe electrospray ionization mass spectrometry. Metabolomics : Official journal of the Metabolomic Society\| PubMed ID: 30830369	2018
Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system. Lipids in health and disease\| PubMed ID: 30885208	2019
Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits. Journal of vascular research\| PubMed ID: 30947215	2019
Several circulating miRNAs related to hyperlipidemia and atherosclerotic cardiovascular diseases. Lipids in health and disease\| PubMed ID: 31010436	2019
Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons. Chemosphere\| PubMed ID: 31102917	2019
Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells. European journal of pharmacology\| PubMed ID: 31310754	2019
Connexin43 Contributes to Inflammasome Activation and Lipopolysaccharide-Initiated Acute Renal Injury Modulation of Intracellular Oxidative Status. Antioxidants & redox signaling\| PubMed ID: 31319679	2019
Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis. Lipids in health and disease\| PubMed ID: 31870448	2019
Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits. Journal of cellular and molecular medicine\| PubMed ID: 32126159	2020
iMarmot: an integrative platform for comparative and functional genomics of marmots. BMC genomics\| PubMed ID: 32228437	2020
Genetic and molecular features for hepadnavirus and plague infections in the Himalayan marmot. Genome\| PubMed ID: 32308030	2020
Endothelial Lipase Exerts its Anti-Atherogenic Effect through Increased Catabolism of β-VLDLs. Journal of atherosclerosis and thrombosis\| PubMed ID: 32448826	2020
Apolipoprotein CIII Deficiency Protects Against Atherosclerosis in Knockout Rabbits. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 32757647	2020
"Coral Reef"-Like Calcifications: Communities of Uncomplicated Calcified Nodules. Journal of atherosclerosis and thrombosis\| PubMed ID: 32779624	2020
Human apolipoprotein A-II reduces atherosclerosis in knock-in rabbits. Atherosclerosis\| PubMed ID: 33296791	2021