Anthony A. James

Anthony A. James

Department of Molecular Biology and Biochemistry, University of California, Irvine (UCI)

Affiliated withUniversity of California, Irvine (UCI)University of California, IrvineUniversity of California

Research Area

Biography

Anthony A. James, PhD is Donald Bren Professor and Distinguished Professor of Microbiology & Molecular Genetics (School of Medicine) and Molecular Biology & Biochemistry (School of Biological Sciences) at the University of California, Irvine. He is a member of the National Academy of Sciences USA. His research group uses genetics as the basis for synthetic approaches to prevent transmission of mosquito-borne diseases. Contributions include the development of mosquito transgenesis procedures, engineered genes that interfere with malaria parasite or dengue virus development in mosquitoes, a population-suppression strain based on flightless female mosquitoes and gene-drive systems to spread beneficial genes quickly through mosquito populations.

Dr. James received his Bachelor of Science and PhD degrees at UCI. He went to Boston in 1979 for postdoctoral work (Harvard Medical School and Brandeis University) and joined the faculty at the Harvard School of Public Health in 1985. He returned to his alma mater in 1989, where he is today. Active and past support include multiple grants from the National Institutes of Health (USA), the Grand Challenges in Global Health initiative, the Bill and Melinda Gates Foundation, the Burroughs-Wellcome Fund, the John D. and Catherine T. MacArthur Foundation and the W.M. Keck Foundation. In addition to being elected to the National Academy of Sciences (USA) in 2006, he received numerous other awards including the Nan-Yao Su (2009) Award for Innovation and Creativity in Entomology from the Entomological Society of America, was a co-recipient of the Premio de Investgación Médica Dr. Jorge Rosenkranz (2008), a recipient of the Burroughs-Wellcome New Initiatives in Malaria Award (2000) and the Burroughs-Wellcome Scholar Award in Molecular Parasitology (1994). He was named a Fellow of the Royal Entomological Society of London (1992), Fellow of the American Association for the Advancement of Science (1994), Fellow of the Society, Entomological Society of America (2011) and Fellow of the American Society of Tropical Medicine and Hygiene (2012). In 2009, he was awarded the UCI Medal. He has published over 200 papers, reviews and policy documents and has provided guidance to 34 graduate students and postdoctoral fellows. He was a founding editor of the journal Insect Molecular Biology and has served on the editorial boards of PLoS Neglected Tropical Diseases, Experimental Parasitology and Entomological Research. He is a member of the American Society of Tropical Medicine and Hygiene, American Committee on Vector Entomology, American Association for the Advancement of Science, American Society of Parasitology, Royal Entomological Society, Entomological Society of America, Genetics Society of America and Society of Vector Ecology.

JoVE Journal Publications

ArticleTotal : 10
Year
Injection of dsRNA into Female A. aegypti Mosquitos
Publication title

Cited by 8

2007
2007
2007
2007
2007

Other Publications

Article
Year
Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 9520437

1998
Mariner transposition and transformation of the yellow fever mosquito, Aedes aegypti.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 9520438

1998
Trapping cDNAs encoding secreted proteins from the salivary glands of the malaria vector Anopheles gambiae.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 9990055

1999
Inhibition of luciferase expression in transgenic Aedes aegypti mosquitoes by Sindbis virus expression of antisense luciferase RNA.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 10557332

1999
Genetics of mosquito vector competence.

Microbiology and molecular biology reviews : MMBR| PubMed ID: 10704476

2000
Engineering blood meal-activated systemic immunity in the yellow fever mosquito, Aedes aegypti.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 10908672

2000
Robust gut-specific gene expression in transgenic Aedes aegypti mosquitoes.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 11005862

2000
What's that buzz? Mosquitoes and fruit flies commingle.

Parasitology today (Personal ed.)| PubMed ID: 11121841

2000
2002
Germline transformants spreading out to many insect species.

Advances in genetics| PubMed ID: 12000097

2002
2002
Engineering mosquito resistance to malaria parasites: the avian malaria model.

Insect biochemistry and molecular biology| PubMed ID: 12225922

2002
Malaria control with genetically manipulated insect vectors.

Science (New York, N.Y.)| PubMed ID: 12364786

2002
The major salivary gland antigens of Culex quinquefasciatus are D7-related proteins.

Insect biochemistry and molecular biology| PubMed ID: 12459201

2003
Engineering Plasmodium-refractory phenotypes in mosquitoes.

Trends in parasitology| PubMed ID: 12957511

2003
Blocking malaria parasite invasion of mosquito salivary glands.

The Journal of experimental biology| PubMed ID: 14506217

2003
Gene vector and transposable element behavior in mosquitoes.

The Journal of experimental biology| PubMed ID: 14506218

2003
2003
2004
2004
2004
Microarray analysis for identification of Plasmodium-refractoriness candidate genes in mosquitoes.

Genome / National Research Council Canada = Génome / Conseil national de recherches Canada| PubMed ID: 15644964

2004
Gene drive systems in mosquitoes: rules of the road.

Trends in parasitology| PubMed ID: 15664528

2005
2005
2005
2005
2006
Structure and expression of the lipophorin-encoding gene of the malaria vector, Anopheles gambiae.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology| PubMed ID: 16524752

2006
Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 16537508

2006
2006
2006
2006
2006
Biochemical mechanisms leading to tryptophan 2,3-dioxygenase activation.

Archives of insect biochemistry and physiology| PubMed ID: 17212352

2007
nanos gene control DNA mediates developmentally regulated transposition in the yellow fever mosquito Aedes aegypti.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 17548819

2007
Genetic control of malaria parasite transmission: threshold levels for infection in an avian model system.

The American journal of tropical medicine and hygiene| PubMed ID: 17556613

2007
2007
Molecular genetic manipulation of vector mosquitoes.

Cell host & microbe| PubMed ID: 18996342

2008
Gene expression studies in mosquitoes.

Advances in genetics| PubMed ID: 19161831

2008
Comparative genomics allows the discovery of cis-regulatory elements in mosquitoes.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 19211788

2009
2009
A transcriptome analysis of the Aedes aegypti vitellogenic fat body.

Journal of insect science (Online)| PubMed ID: 19537968

2006
2009
2010
Female-specific flightless phenotype for mosquito control.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 20176967

2010
2010
2010
Proteomics reveals novel components of the Anopheles gambiae eggshell.

Journal of insect physiology| PubMed ID: 20433845

2010
2010
Dengue Fever in mainland China.

The American journal of tropical medicine and hygiene| PubMed ID: 20810836

2010
2010
2010
Genetics-based field studies prioritize safety.

Science (New York, N.Y.)| PubMed ID: 21273469

2011
2011
Genetic elimination of dengue vector mosquitoes.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 21383140

2011
2011
2011
Safety of genetically modified mosquitoes.

JAMA : the journal of the American Medical Association| PubMed ID: 21610238

2011
Why RIDL is not SIT.

Trends in parasitology| PubMed ID: 21659002

2011
Ecology. Mosquito trials.

Science (New York, N.Y.)| PubMed ID: 22076370

2011
2012
Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 22689959

2012
2012
2013
Strongyloidiasis: an emerging infectious disease in China.

The American journal of tropical medicine and hygiene| PubMed ID: 23468357

2013
Exogenous gypsy insulator sequences modulate transgene expression in the malaria vector mosquito, Anopheles stephensi.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 23584017

2013
2013
2013
2013
2013
2013
2013
2013
Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 24297936

2013
2013
2014
2014
2014
Collagen-binding protein, Aegyptin, regulates probing time and blood feeding success in the dengue vector mosquito, Aedes aegypti.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 24778255

2014
2014
2014
2014
2014
Site-specific, TALENs-mediated transformation of Bombyx mori.

Insect biochemistry and molecular biology| PubMed ID: 25460511

2014
2015
2015
Protein phosphorylation during Plasmodium berghei gametogenesis.

Experimental parasitology| PubMed ID: 26008612

2015
2015
Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 26483478

2015
Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 26598698

2015
2016
2016
2016
Sexually dimorphic traits in the silkworm, Bombyx mori, are regulated by doublesex.

Insect biochemistry and molecular biology| PubMed ID: 27867075

2017
2017
2017
2017
2017
Rules of the road for insect gene drive research and testing.

Nature biotechnology| PubMed ID: 28787415

2017
2017
2018
2018
Silkworm genetic sexing through W chromosome-linked, targeted gene integration.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 30104361

2018
2019
2020
2019
2020
2020
Next-generation gene drive for population modification of the malaria vector mosquito, .

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 32839345

2020
The [] Gene Family Modulates Dengue Virus Infection in .

International journal of molecular sciences| PubMed ID: 33053895

2020
2020
2020