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The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
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Chapters
- 00:05Title
- 01:23Modifying Polymeric Surfaces with recCD47
- 04:15Immunoassay Quantification of recCD47 on Modified Surfaces
- 06:42Chandler Loop Apparatus Protocol
- 08:22Results: Analysis of recCD47-modified Polyurethane
- 09:42Conclusion
Blood exposure to polymeric blood conduits initiates the foreign body reaction that has been implicated in clinical complications. Here, the Chandler Loop Apparatus, an experimental tool mimicking blood perfusion through these conduits, is described. Appendage of recombinant CD47 results in decreased evidence of the foreign body reaction on these conduits.
