Carol M. Troy

Department of Pathology and Cell Biology, Columbia University Medical Center

Affiliated withColumbia University Medical Center Columbia University Columbia College

Research Area

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 40	2015
Publication title Cited by 9	2021
Publication title Cited by 4	2022
Publication title Cited by 3	2022

Other Publications

Article	Year
Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9045720	1997
Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9437005	1998
Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9801360	1998
Caspase-2 mediates neuronal cell death induced by beta-amyloid. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 10662829	2000
Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11438576	2001
Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases. The Journal of biological chemistry\| PubMed ID: 12097334	2002
Caspases on the brain. Journal of neuroscience research\| PubMed ID: 12111795	2002
Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein. Neurobiology of aging\| PubMed ID: 15212831	2004
Balancing neuronal death. Journal of neuroscience research\| PubMed ID: 15372573	2004
Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15537872	2004
Caspase function in neuronal death: delineation of the role of caspases in ischemia. Current drug targets. CNS and neurological disorders\| PubMed ID: 15723613	2005
Cell cycle molecules define a pathway required for neuron death in development and disease. Biochimica et biophysica acta\| PubMed ID: 17229557	2007
Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17251431	2007
Mechanisms of neuronal death in disease: defining the models and the players. The Biochemical journal\| PubMed ID: 18800967	2008
Caspase-2: vestigial remnant or master regulator? Science signaling\| PubMed ID: 18812565	2008
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19176810	2009
Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19587290	2009
Cystatin C protects neuronal cells from amyloid-beta-induced toxicity. Journal of Alzheimer's disease : JAD\| PubMed ID: 20157244	2010
Regulation of caspases in the nervous system implications for functions in health and disease. Progress in molecular biology and translational science\| PubMed ID: 21238939	2011
Endogenous amyloid-Î² is necessary for hippocampal synaptic plasticity and memory. Annals of neurology\| PubMed ID: 21472769	2011
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21677173	2011
Neuronal caspase 2 activity and function requires RAIDD, but not PIDD. The Biochemical journal\| PubMed ID: 22515271	2012
Caspase inhibitors: prospective therapies for stroke. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 22645109	2013
Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection. Molecular neurodegeneration\| PubMed ID: 23217200	2012
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. Nature communications\| PubMed ID: 23748737	2013
Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death. The Biochemical journal\| PubMed ID: 23815625	2013
Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling. Brain : a journal of neurology\| PubMed ID: 24727569	2014
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions. Cell\| PubMed ID: 25171414	2014
Caspase-9 mediates photoreceptor death after blunt ocular trauma. Investigative ophthalmology & visual science\| PubMed ID: 25190658	2014
Caspases: therapeutic targets in neurologic disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 25339539	2015
Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. American journal of human genetics\| PubMed ID: 27773430	2016
Caspase-2 and tau-a toxic partnership? Nature medicine\| PubMed ID: 27824824	2016
Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice. ASN neuro\| PubMed ID: 32493127	2020
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion. Nature communications\| PubMed ID: 32576823	2020
Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion. Nature communications\| PubMed ID: 32647109	2020
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease. Frontiers in pharmacology\| PubMed ID: 34305609	2021