Laura E. Niklason

Department of Biomedical Engineering, Yale University

Affiliated withYale University Yale University School of Medicine Yale School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 31	2011
Publication title Cited by 43	2011
Publication title Cited by 7	2022

Other Publications

Article	Year
Bioreactors and bioprocessing for tissue engineering. Annals of the New York Academy of Sciences\| PubMed ID: 12081903	2002
Bioreactors and bioprocessing: breakout session summary. Annals of the New York Academy of Sciences\| PubMed ID: 12081905	2002
Tissue engineering of the lymphatic system. Annals of the New York Academy of Sciences\| PubMed ID: 12543713	2002
Vascular endothelial growth factor expression in pig latissimus dorsi myocutaneous flaps after ischemia reperfusion injury. Plastic and reconstructive surgery\| PubMed ID: 12560698	2003
Requirements for growing tissue-engineered vascular grafts. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 12684159	2003
Human arteries engineered in vitro. EMBO reports\| PubMed ID: 12776184	2003
Effects of polyglycolic acid on porcine smooth muscle cell growth and differentiation. Journal of biomedical materials research. Part A\| PubMed ID: 14517889	2003
Engineering porcine arteries: effects of scaffold modification. Journal of biomedical materials research. Part A\| PubMed ID: 14517890	2003
Decellularized native and engineered arterial scaffolds for transplantation. Cell transplantation\| PubMed ID: 14579934	2003
Gene therapy in tissue-engineered blood vessels. Tissue engineering\| PubMed ID: 14670116	2003
Sepsis in the interventional radiology patient. Journal of vascular and interventional radiology : JVIR\| PubMed ID: 15064334	2004
Clonal population of adult stem cells: life span and differentiation potential. Cell transplantation\| PubMed ID: 15129755	2004
Immunohistochemical identification of vascular endothelial growth factor in pig latissimus dorsi musculocutaneous flaps following ischemia-reperfusion injury. Annals of plastic surgery\| PubMed ID: 15385779	2004
Engineering skeletal myoblasts: roles of three-dimensional culture and electrical stimulation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15550526	2005
A system for the direct co-culture of endothelium on smooth muscle cells. Biomaterials\| PubMed ID: 15722134	2005
Antihuman factor V antibodies after use of relatively pure bovine thrombin. The Annals of thoracic surgery\| PubMed ID: 15734434	2005
Use of hemoglobin raffimer for postoperative life-threatening anemia in a Jehovah's Witness. Canadian journal of anaesthesia = Journal canadien d'anesthÃ©sie\| PubMed ID: 15814750	2005
Blood vessels engineered from human cells. Lancet\| PubMed ID: 15964449	2005
Effects of copper and cross-linking on the extracellular matrix of tissue-engineered arteries. Cell transplantation\| PubMed ID: 16180655	2005
Effects of copper and cross-linking on the extracellular matrix of tissue-engineered arteries. Cell transplantation\| PubMed ID: 16454361	2005
Relevance and safety of telomerase for human tissue engineering. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16477025	2006
Feasibility of vitrification as a storage method for tissue-engineered blood vessels. Tissue engineering\| PubMed ID: 16548687	2006
Blood vessels engineered from human cells. Trends in cardiovascular medicine\| PubMed ID: 16781948	2006
Angiogenesis therapies for cardiovascular disease. Current opinion in anaesthesiology\| PubMed ID: 17021436	2003
Mechanical properties and compositions of tissue engineered and native arteries. Annals of biomedical engineering\| PubMed ID: 17206488	2007
Role of vascular mitogens in subarachnoid hemorrhage-associated cerebral vasculopathy. Neurocritical care\| PubMed ID: 17290093	2006
An ultrastructural analysis of collagen in tissue engineered arteries. Annals of biomedical engineering\| PubMed ID: 17566861	2007
Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs). FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18199698	2008
A microstructurally motivated model of the mechanical behavior of tissue engineered blood vessels. Annals of biomedical engineering\| PubMed ID: 18720007	2008
Influence of culture medium on smooth muscle cell differentiation from human bone marrow-derived mesenchymal stem cells. Tissue engineering. Part A\| PubMed ID: 19115826	2009
Development of decellularized human umbilical arteries as small-diameter vascular grafts. Tissue engineering. Part A\| PubMed ID: 19207043	2009
Novel utilization of serum in tissue decellularization. Tissue engineering. Part C, Methods\| PubMed ID: 19419244	2010
Effects of mechanical stretch on collagen and cross-linking in engineered blood vessels. Cell transplantation\| PubMed ID: 19500474	2009
A biocompatible endothelial cell delivery system for in vitro tissue engineering. Cell transplantation\| PubMed ID: 19500475	2009
Scaffold-free vascular tissue engineering using bioprinting. Biomaterials\| PubMed ID: 19664819	2009
Utility of telomerase-pot1 fusion protein in vascular tissue engineering. Cell transplantation\| PubMed ID: 19878625	2010
Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19955446	2010
Porcine endothelial cells cocultured with smooth muscle cells became procoagulant in vitro. Tissue engineering. Part A\| PubMed ID: 20055662	2010
A novel flow bioreactor for in vitro microvascularization. Tissue engineering. Part C, Methods\| PubMed ID: 20170423	2010
Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior. Journal of neurochemistry\| PubMed ID: 20456017	2010
Tissue-engineered lungs for in vivo implantation. Science (New York, N.Y.)\| PubMed ID: 20576850	2010
Bioreactor for the long-term culture of lung tissue. Cell transplantation\| PubMed ID: 21092411	2011
Development of novel biodegradable polymer scaffolds for vascular tissue engineering. Tissue engineering. Part A\| PubMed ID: 21143045	2011
Readily available tissue-engineered vascular grafts. Science translational medicine\| PubMed ID: 21289273	2011
Use of human mesenchymal stem cells as alternative source of smooth muscle cells in vessel engineering. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21431526	2011
Matrix Composition and Mechanics of Decellularized Lung Scaffolds. Cells, tissues, organs\| PubMed ID: 21502745	2011
Building stronger microvessels. Nature biotechnology\| PubMed ID: 21552239	2011
Decellularized tissue-engineered blood vessel as an arterial conduit. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21571635	2011
An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia. Journal of cardiovascular translational research\| PubMed ID: 21748530	2011
Smooth muscle and other cell sources for human blood vessel engineering. Cells, tissues, organs\| PubMed ID: 22041291	2012
Allogeneic human tissue-engineered blood vessel. Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter\| PubMed ID: 22056286	2011
Inhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22095981	2011
Cardiovascular regenerative biology. Cells, tissues, organs\| PubMed ID: 22179179	2012
Engineered zinc-finger proteins can compensate genetic haploinsufficiency by transcriptional activation of the wild-type allele: application to Willams-Beuren syndrome and supravalvular aort... Human gene therapy\| PubMed ID: 22891920	2012
Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. American journal of respiratory and critical care medicine\| PubMed ID: 22936357	2012
Microfluidic artificial "vessels" for dynamic mechanical stimulation of mesenchymal stem cells. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 23114826	2012
Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix. The Journal of clinical investigation\| PubMed ID: 24135142	2013
Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor. Biomaterials\| PubMed ID: 24144903	2014
The use of optical clearing and multiphoton microscopy for investigation of three-dimensional tissue-engineered constructs. Tissue engineering. Part C, Methods\| PubMed ID: 24251630	2014
Construction of tissue-engineered small-diameter vascular grafts in fibrin scaffolds in 30 days. Tissue engineering. Part A\| PubMed ID: 24320793	2014
Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds. Tissue engineering. Part A\| PubMed ID: 24393055	2014
Engineering of arteries in vitro. Cellular and molecular life sciences : CMLS\| PubMed ID: 24399290	2014
A call to craft. Science translational medicine\| PubMed ID: 24401937	2014
Future prospects for tissue engineered lung transplantation: decellularization and recellularization-based whole lung regeneration. Organogenesis\| PubMed ID: 24488093	2014
Vascular Tissue Engineering: Building Perfusable Vasculature for Implantation. Current opinion in chemical engineering\| PubMed ID: 24533306	2014
Strategies for whole lung tissue engineering. IEEE transactions on bio-medical engineering\| PubMed ID: 24691527	2014
Influence of pH on extracellular matrix preservation during lung decellularization. Tissue engineering. Part C, Methods\| PubMed ID: 24735501	2014
Extracellular matrix as a driver for lung regeneration. Annals of biomedical engineering\| PubMed ID: 25344351	2015
Efficient intratracheal delivery of airway epithelial cells in mice and pigs. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 25416381	2015
Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials\| PubMed ID: 25433608	2015
Click-coated, heparinized, decellularized vascular grafts. Acta biomaterialia\| PubMed ID: 25463496	2015
PCH-2 regulates Caenorhabditis elegans lifespan. Aging\| PubMed ID: 25635513	2015
Osteogenic performance of donor-matched human adipose and bone marrow mesenchymal cells under dynamic culture. Tissue engineering. Part A\| PubMed ID: 25668104	2015
Design and Use of a Novel Bioreactor for Regeneration of Biaxially Stretched Tissue-Engineered Vessels. Tissue engineering. Part C, Methods\| PubMed ID: 25669988	2015
Fate of distal lung epithelium cultured in a decellularized lung extracellular matrix. Tissue engineering. Part A\| PubMed ID: 25789725	2015
Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor. Biomaterials\| PubMed ID: 25890758	2015
Development of Lung Epithelium from Induced Pluripotent Stem Cells. Current transplantation reports\| PubMed ID: 26052480	2015
Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16. Oncotarget\| PubMed ID: 26299918	2015
Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli. Tissue engineering. Part A\| PubMed ID: 26414101	2015
Production of decellularized porcine lung scaffolds for use in tissue engineering. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 26426090	2015
Sterilization of Lung Matrices by Supercritical Carbon Dioxide. Tissue engineering. Part C, Methods\| PubMed ID: 26697757	2016
Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 26749424	2016
A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium. Cell medicine\| PubMed ID: 26858899	2015
Biomimetic Culture Reactor for Whole-Lung Engineering. BioResearch open access\| PubMed ID: 27088061	2016
Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries. Tissue engineering. Part C, Methods\| PubMed ID: 27108525	2016
Ventilation-Based Decellularization System of the Lung. BioResearch open access\| PubMed ID: 27186445	2016
Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials. Lancet (London, England)\| PubMed ID: 27203778	2016
Implantable tissue-engineered blood vessels from human induced pluripotent stem cells. Biomaterials\| PubMed ID: 27336184	2016
Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine. Biomaterials\| PubMed ID: 27344365	2016
New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27386939	2016
Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice. Blood\| PubMed ID: 27471233	2016
Engineered Tissue-Stent Biocomposites as Tracheal Replacements. Tissue engineering. Part A\| PubMed ID: 27520928	2016
Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27628133	2019
Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices. Acta biomaterialia\| PubMed ID: 27693690	2016
Lung regeneration: steps toward clinical implementation and use. Current opinion in anaesthesiology\| PubMed ID: 27922848	2017
Controlled gas exchange in whole lung bioreactors. Journal of tissue engineering and regenerative medicine\| PubMed ID: 28083925	2018
Historical Perspective and Future Direction of Blood Vessel Developments. Cold Spring Harbor perspectives in medicine\| PubMed ID: 28348177	2018
Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix. Biomaterials\| PubMed ID: 28667900	2017
Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells. Scientific reports\| PubMed ID: 28814761	2017
Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. Cell transplantation\| PubMed ID: 28901188	2017
Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Biomaterials\| PubMed ID: 28942128	2017
Bioengineered lungs generated from human iPSCs-derived epithelial cells on native extracellular matrix. Journal of tissue engineering and regenerative medicine\| PubMed ID: 29024475	2018
A short discourse on vascular tissue engineering. NPJ Regenerative medicine\| PubMed ID: 29057097	2017
Susceptibility of ePTFE vascular grafts and bioengineered human acellular vessels to infection. The Journal of surgical research\| PubMed ID: 29229120	2018
Neuropilin-1 Mediated Arterial Differentiation of Murine Pluripotent Stem Cells. Stem cells and development\| PubMed ID: 29415620	2018
Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration. Cell stem cell\| PubMed ID: 29499149	2018
Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction. The Annals of thoracic surgery\| PubMed ID: 29510094	2018
Extracellular matrix in lung development, homeostasis and disease. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 29524630	2018
Vascularization of Natural and Synthetic Bone Scaffolds. Cell transplantation\| PubMed ID: 30008231	2018
An Ex Vivo Vessel Injury Model to Study Remodeling. Cell transplantation\| PubMed ID: 30095004	2018
Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering. Biomaterials\| PubMed ID: 30754017	2019
Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation. Science translational medicine\| PubMed ID: 30918113	2019
Fas ligand and nitric oxide combination to control smooth muscle growth while sparing endothelium. Biomaterials\| PubMed ID: 31102854	2019
Non-invasive and real-time measurement of microvascular barrier in intact lungs. Biomaterials\| PubMed ID: 31280072	2019
Utilization of Natural Detergent Potassium Laurate for Decellularization in Lung Bioengineering. Tissue engineering. Part C, Methods\| PubMed ID: 31317819	2019
Engineering of human brain organoids with a functional vascular-like system. Nature methods\| PubMed ID: 31591580	2019
Reduced patency in left-sided arteriovenous grafts in a porcine model. Journal of vascular surgery\| PubMed ID: 31699515	2020
Microvessel Network Formation and Interactions with Pancreatic Islets in Three-Dimensional Chip Cultures. Tissue engineering. Part A\| PubMed ID: 31724494	2020
Single-cell connectomic analysis of adult mammalian lungs. Science advances\| PubMed ID: 31840053	2019
Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs. Cell stem cell\| PubMed ID: 31956039	2020
Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease. Journal of vascular surgery\| PubMed ID: 32093913	2020
Bioengineering the Blood-gas Barrier. Comprehensive Physiology\| PubMed ID: 32163210	2020
Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing. Cell reports\| PubMed ID: 32209482	2020
Challenges and novel therapies for vascular access in haemodialysis. Nature reviews. Nephrology\| PubMed ID: 32839580	2020
Bioengineered human blood vessels. Science (New York, N.Y.)\| PubMed ID: 33033191	2020
The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future. Tissue engineering. Part B, Reviews\| PubMed ID: 33045942	2021
Critical Considerations for Regeneration of Vascularized Composite Tissues. Tissue engineering. Part B, Reviews\| PubMed ID: 33115331	2021
Xenogeneic-free generation of vascular smooth muscle cells from human induced pluripotent stem cells for vascular tissue engineering. Acta biomaterialia\| PubMed ID: 33130306	2021
Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells under Xenogeneic-free Conditions for Vascular Tissue Engineering. Acta biomaterialia\| PubMed ID: 33166710	2021
Efficient and Functional Endothelial Repopulation of Whole Lung Organ Scaffolds. ACS biomaterials science & engineering\| PubMed ID: 33440555	2017
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. PLoS biology\| PubMed ID: 33730024	2021
Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation\| PubMed ID: 34030460	2021
An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies. Biomaterials\| PubMed ID: 34087584	2021
Development of a Bioartificial Vascular Pancreas. Journal of tissue engineering\| PubMed ID: 34262686	2021
Microvascular fluid flow in ex vivo and engineered lungs. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 34554016	2021
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds. Frontiers in bioengineering and biotechnology\| PubMed ID: 34869270	2021
307.8: Novel Approach in Pancreatic Islet Transplantation: Acellular Vessel. Transplantation\| PubMed ID: 34908334	2021
Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience. Anesthesia and analgesia\| PubMed ID: 34928890	2021