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JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
Procedure for Lung Engineering
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Procedure for Lung Engineering

Article DOI: 10.3791/2651
March 8th, 2011 •
*1, *2, 1,3
1Department of Biomedical Engineering, Yale University, 2Department of Biomedical Engineering, School of Medicine, Duke University, 3Department of Anesthesia, Yale University
* These authors contributed equally

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Summary
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March 8th, 2011

We have developed a decellularized lung extracellular matrix and novel biomimetic bioreactor that can be used to generate functional lung tissue. By seeding cells into the matrix and culturing in the bioreactor, we generate tissue that demonstrates effective gas exchange when transplanted in vivo for short periods of time.

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