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Journal / Bioengineering / Procedure for Lung Engineering
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Bioengineering

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JoVE Journal Bioengineering
Procedure for Lung Engineering
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Procedure for Lung Engineering

Article DOI: 10.3791/2651 • 12:50 min • March 8th, 2011
March 8th, 2011 •
*1, *2, 1,3
1Department of Biomedical Engineering, Yale University, 2Department of Biomedical Engineering, School of Medicine, Duke University, 3Department of Anesthesia, Yale University
* These authors contributed equally

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Summary
Automatic Translation

We have developed a decellularized lung extracellular matrix and novel biomimetic bioreactor that can be used to generate functional lung tissue. By seeding cells into the matrix and culturing in the bioreactor, we generate tissue that demonstrates effective gas exchange when transplanted in vivo for short periods of time.

Tags

Lung Engineering Lung Tissue Lung Cancer Chronic Lung Diseases Chronic Obstructive Pulmonary Disease Mortality Regenerative Medicine Lung Tissue Regeneration In Vitro Lung Tissue Generation Acellular Lung Extracellular Matrix Scaffold Basement Membrane Bioreactor Pulmonary Epithelium Vascular Endothelium Gas Exchange Repopulation Of Lung Matrix
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