David J. Harrison

Breakthrough Breast Cancer Research Unit, University of Edinburgh

Affiliated withUniversity of Edinburgh University of St Andrews

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 11	2011
Publication title Cited by 27	2011
Publication title Cited by 12	2013

Other Publications

Article	Year
Glutathione and p53 independently mediate responses against oxidative stress in ES cells. Free radical biology & medicine\| PubMed ID: 11796208	2002
Counting alleles to predict recurrence of early-stage colorectal cancers. Lancet\| PubMed ID: 11812558	2002
Lack of health insurance and overall health. The New England journal of medicine\| PubMed ID: 11856806	2002
Functional analysis of mouse hepatocytes differing in DNA content: volume, receptor expression, and effect of IFNgamma. Journal of cellular physiology\| PubMed ID: 12064456	2002
Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes. Oncogene\| PubMed ID: 12096346	2002
Genetic interactions between the Wilms' tumor 1 gene and the p53 gene. Cancer research\| PubMed ID: 12438257	2002
Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest. BMC cell biology\| PubMed ID: 12443538	2002
Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 12594235	2003
Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. The Journal of pathology\| PubMed ID: 12635140	2003
MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers. Oncogene\| PubMed ID: 12776203	2003
Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology\| PubMed ID: 12806622	2003
Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms. Human pathology\| PubMed ID: 12827612	2003
Thermal denaturation of spinach plastocyanin: effect of copper site oxidation state and molecular oxygen. Biochemistry\| PubMed ID: 12939160	2003
TNF-alpha induced DNA damage in primary murine hepatocytes. International journal of molecular medicine\| PubMed ID: 14612962	2003
While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. Molecular and cellular biology\| PubMed ID: 14645534	2003
Additive effect of p53, p21 and Rb deletion in triple knockout primary hepatocytes. Oncogene\| PubMed ID: 14647424	2004
Reducing exposure to laboratory animal allergens. Comparative medicine\| PubMed ID: 14655990	2003
Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells. Cancer letters\| PubMed ID: 15072830	2004
Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. The Journal of pathology\| PubMed ID: 15258993	2004
p21(Waf1/Cip1) regulates proliferation and apoptosis in airway epithelial cells and alternative forms have altered binding activities. Experimental lung research\| PubMed ID: 15524404	2004
Potential of hematopoietic stem cell therapy in hepatology: a critical review. Stem cells (Dayton, Ohio)\| PubMed ID: 15536182	2004
Induction of p21 and nuclear accumulation of TAp73alpha and c-abl during apoptosis of cisplatin-treated primary pancreatic acinar cells. International journal of oncology\| PubMed ID: 15547703	2004
Improved retention of zymogen granules in cultured murine pancreatic acinar cells and induction of acinar-ductal transdifferentiation in vitro. Pancreas\| PubMed ID: 15714137	2005
p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells. Oncogene\| PubMed ID: 15735758	2005
Pharmacoeconomic analysis of sertraline treatment of depression in patients with unstable angina or a recent myocardial infarction. The Journal of clinical psychiatry\| PubMed ID: 15766301	2005
Integrin characterization in pulmonary bronchioles. Experimental and molecular pathology\| PubMed ID: 15939420	2005
ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates. The Journal of pathology\| PubMed ID: 15954165	2005
Hematopoietic stem cell trafficking in liver injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16051689	2005
Impact of atypical antipsychotics on outcomes of care in schizophrenia. The American journal of managed care\| PubMed ID: 16180964	2005
The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice. Experimental cell research\| PubMed ID: 16271715	2006
Relationship between preventative physical health care and mental health in individuals with schizophrenia: a survey of caregivers. Mental health services research\| PubMed ID: 16320105	2005
Effect of initial ziprasidone dose on length of therapy in schizophrenia. Schizophrenia research\| PubMed ID: 16545543	2006
Effect of initial ziprasidone dose on treatment persistence in schizophrenia. Schizophrenia research\| PubMed ID: 16545945	2006
Growth factor attenuation of IFNgamma-mediated hepatocyte apoptosis requires p21waf-1. International journal of experimental pathology\| PubMed ID: 16875492	2006
Change in framingham risk score in patients with schizophrenia: a post hoc analysis of a randomized, double-blind, 6-week trial of ziprasidone and olanzapine. Primary care companion to the Journal of clinical psychiatry\| PubMed ID: 17245453	2006
Microarray analysis of gene expression of mouse hepatocytes of different ploidy. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 17726633	2007
Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest. BMC cancer\| PubMed ID: 18021445	2007
Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396). Transgenic research\| PubMed ID: 18040647	2008
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Experimental cell research\| PubMed ID: 18062963	2008
Dynamic computational modeling in the search for better breast cancer drug therapy. Pharmacogenomics\| PubMed ID: 18086005	2007
Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. DNA repair\| PubMed ID: 18162445	2008
The cost of treating skeletal-related events in patients with prostate cancer. The American journal of managed care\| PubMed ID: 18471035	2008
TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status. BMC cancer\| PubMed ID: 18611248	2008
Beta1 integrin in tissue remodelling and repair: from phenomena to concepts. Pharmacology & therapeutics\| PubMed ID: 18708090	2008
Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans. PloS one\| PubMed ID: 19436735	2009
WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3. Cancer research\| PubMed ID: 19458077	2009
Structure, properties, and engineering of the major zinc binding site on human albumin. The Journal of biological chemistry\| PubMed ID: 19520864	2009
The impact of itch symptoms in psoriasis: results from physician interviews and patient focus groups. Health and quality of life outcomes\| PubMed ID: 19580674	2009
Systems pathology--taking molecular pathology into a new dimension. Nature reviews. Clinical oncology\| PubMed ID: 19581910	2009
Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab. Cancer research\| PubMed ID: 19638581	2009
Modulation of HER3 is a marker of dynamic cell signaling in ovarian cancer: implications for pertuzumab sensitivity. Molecular cancer research : MCR\| PubMed ID: 19737968	2009
How can systems pathology help us personalize cancer therapy? Discovery medicine\| PubMed ID: 19788873	2009
The importance of growth factors and steroid hormones in ovarian cancer. Onkologie\| PubMed ID: 19887864	2009
Prognostic relevance of DNA copy number changes in colorectal cancer. The Journal of pathology\| PubMed ID: 19911421	2010
Bone marrow stem cells contribute to alcohol liver fibrosis in humans. Stem cells and development\| PubMed ID: 20025456	2010
Comparison of methods for measuring dose escalation of the subcutaneous TNF antagonists for rheumatoid arthritis patients treated in routine clinical practice. Current medical research and opinion\| PubMed ID: 20429830	2010
Etanercept treatment patterns in managed-care patients with psoriasis or psoriatic arthritis. Journal of medical economics\| PubMed ID: 20459298	2010
Pertuzumab for the treatment of ovarian cancer. Expert opinion on biological therapy\| PubMed ID: 20465533	2010
Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells. International journal of oncology\| PubMed ID: 20514394	2010
Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer. Breast cancer research : BCR\| PubMed ID: 20569502	2010
Validation and response to treatment of a pruritus self-assessment tool in patients with moderate to severe psoriasis. Journal of the American Academy of Dermatology\| PubMed ID: 20599294	2010
Dosing patterns and costs of tumor necrosis factor inhibitor use for rheumatoid arthritis. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists\| PubMed ID: 20651319	2010
Cancer systems biology. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20824475	2010
Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. Cancer research\| PubMed ID: 20861192	2010
Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS genetics\| PubMed ID: 20885785	2010
Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition. Cellular signalling\| PubMed ID: 20951800	2011
Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 21334202	2011
An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. PloS one\| PubMed ID: 21347235	2011
Routinely obtained diagnostic material as a source of RNA for personalized medicine in lung cancer patients. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer\| PubMed ID: 21358345	2011
Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21368160	2011
Utilizing mRNA extracted from small, archival formalin-fixed paraffin-embedded prostate samples for translational research: assessment of the effect of increasing sample age and storage temp... International urology and nephrology\| PubMed ID: 21448682	2011
An analytical approach differentiates between individual and collective cancer invasion. Analytical cellular pathology (Amsterdam)\| PubMed ID: 21483102	2011
What can molecular pathology contribute to the management of renal cell carcinoma? Nature reviews. Urology\| PubMed ID: 21487387	2011
Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21571868	2011
Two possible mechanisms of epithelial to mesenchymal transition in invasive ductal breast cancer. Clinical & experimental metastasis\| PubMed ID: 21789718	2011
Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum. Behavioural brain research\| PubMed ID: 21871498	2011
Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy. PloS one\| PubMed ID: 21909357	2011
Health-related quality of life of pediatric patients with moderate to severe plaque psoriasis: comparisons to four common chronic diseases. European journal of pediatrics\| PubMed ID: 21960290	2011
Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition. Cellular signalling\| PubMed ID: 21996585	2012
Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture. Biomaterials\| PubMed ID: 22048005	2012
GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines. BMC cancer\| PubMed ID: 22051164	2011
Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sect... Analytical chemistry\| PubMed ID: 22077717	2011
Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 22085636	2011
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes. Genome research\| PubMed ID: 22106369	2011
Annual costs of tumor necrosis factor inhibitors using real-world data in a commercially insured population in the United States. Journal of medical economics\| PubMed ID: 22115327	2011
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression. Nucleic acids research\| PubMed ID: 22323521	2012
The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma. PloS one\| PubMed ID: 22363672	2012
HER2 expression in ovarian carcinoma: caution and complexity in biomarker analysis. Journal of clinical pathology\| PubMed ID: 22412045	2012
Allosteric modulation of beta1 integrin function induces lung tissue repair. Advances in pharmacological sciences\| PubMed ID: 22505883	2012
Diversity of matriptase expression level and function in breast cancer. PloS one\| PubMed ID: 22514623	2012
Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget\| PubMed ID: 22689141	2012
Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation. Journal of proteomics\| PubMed ID: 22796569	2012
Characterising the tumour morphological response to therapeutic intervention: an ex vivo model. Disease models & mechanisms\| PubMed ID: 22888098	2013
Clinical Utility of an Epigenetic Assay to Detect Occult Prostate Cancer in Histopathologically Negative Biopsies: Results of the MATLOC Study. The Journal of urology\| PubMed ID: 22999998	2012
Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer. Cellular signalling\| PubMed ID: 23000339	2013
Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns. Genome biology\| PubMed ID: 23034185	2012
New strategies for targeting the hypoxic tumour microenvironment in breast cancer. Cancer treatment reviews\| PubMed ID: 23063837	2013
A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen. BMC systems biology\| PubMed ID: 23134774	2012