Wieland B. Huttner

Max Planck Institute of Molecular Cell Biology and Genetics

Affiliated withMax Planck Institute of Molecular Cell Biology and Genetics

Research Area

Biography

N/A

JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 6	2021
Publication title Cited by 3	2023
Publication title Cited by 5	2020

Other Publications

Article	Year
Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12391321	2002
Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. The Journal of biological chemistry\| PubMed ID: 12514187	2003
AC133 antigen, CD133, prominin-1, prominin-2, etc.: prominin family gene products in need of a rational nomenclature. Stem cells (Dayton, Ohio)\| PubMed ID: 12832703	2003
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. Journal of cell science\| PubMed ID: 14625388	2003
Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14963232	2004
Tissue-specific RNA interference in post-implantation mouse embryos using directional electroporation and whole embryo culture. Differentiation; research in biological diversity\| PubMed ID: 15066189	2004
Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. The EMBO journal\| PubMed ID: 15141162	2004
Identification of novel Prominin-1/CD133 splice variants with alternative C-termini and their expression in epididymis and testis. Journal of cell science\| PubMed ID: 15316084	2004
Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. Journal of cell science\| PubMed ID: 15976444	2005
Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16014714	2005
Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system. Current opinion in cell biology\| PubMed ID: 16243506	2005
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16798874	2006
Single-cell detection of microRNAs in developing vertebrate embryos after acute administration of a dual-fluorescence reporter/sensor plasmid. BioTechniques\| PubMed ID: 17191618	2006
Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. The Journal of cell biology\| PubMed ID: 17283184	2007
Cell polarity from cell division. Developmental cell\| PubMed ID: 17488617	2007
On the origin of neurons. Genome biology\| PubMed ID: 17666121	2007
Neuronal and glial cell biology. Current opinion in neurobiology\| PubMed ID: 18093823	2007
Tyrosine O-sulfation. Current protocols in protein science\| PubMed ID: 18429275	2005
Live imaging at the onset of cortical neurogenesis reveals differential appearance of the neuronal phenotype in apical versus basal progenitor progeny. PloS one\| PubMed ID: 18545663	2008
Making bigger brains-the evolution of neural-progenitor-cell division. Journal of cell science\| PubMed ID: 18716282	2008
The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development. Current opinion in cell biology\| PubMed ID: 18930817	2008
Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex. Neuron\| PubMed ID: 18940587	2008
Cytokinesis of neuroepithelial cells can divide their basal process before anaphase. The EMBO journal\| PubMed ID: 18971946	2008
miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development (Cambridge, England)\| PubMed ID: 18997113	2008
Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol. FEBS letters\| PubMed ID: 19302789	2009
Nonselective sister chromatid segregation in mouse embryonic neocortical precursor cells. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 19342402	2009
Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416849	2009
Tis21 expression marks not only populations of neurogenic precursor cells but also new postmitotic neurons in adult hippocampal neurogenesis. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 19482889	2010
Myosin II is required for interkinetic nuclear migration of neural progenitors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805325	2009
Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B. Circulation. Cardiovascular genetics\| PubMed ID: 20011129	2009
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling. Nature neuroscience\| PubMed ID: 20436478	2010
Prominin-1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate. The Prostate\| PubMed ID: 20717901	2011
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20823249	2010
Neural progenitor nuclei IN motion. Neuron\| PubMed ID: 20869589	2010
Cortical progenitor expansion, self-renewal and neurogenesis-a polarized perspective. Current opinion in neurobiology\| PubMed ID: 21036598	2011
Neural stem and progenitor cells shorten S-phase on commitment to neuron production. Nature communications\| PubMed ID: 21224845	2011
Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour. Nature communications\| PubMed ID: 22009035	2011
Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination. Development (Cambridge, England)\| PubMed ID: 22096071	2012
Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 22114084	2012
A new approach to manipulate the fate of single neural stem cells in tissue. Nature neuroscience\| PubMed ID: 22179113	2011
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22753484	2012
Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny. Advances in experimental medicine and biology\| PubMed ID: 23161077	2013
The secondary loss of gyrencephaly as an example of evolutionary phenotypical reversal. Frontiers in neuroanatomy\| PubMed ID: 23805079	2013
Conical expansion of the outer subventricular zone and the role of neocortical folding in evolution and development. Frontiers in human neuroscience\| PubMed ID: 23914167	2013
Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell\| PubMed ID: 24120134	2013
Progenitor networking in the fetal primate neocortex. Neuron\| PubMed ID: 24139029	2013
Integrin αvβ3 and thyroid hormones promote expansion of progenitors in embryonic neocortex. Development (Cambridge, England)\| PubMed ID: 24496617	2014
Neurogenesis during development of the vertebrate central nervous system. EMBO reports\| PubMed ID: 24639559	2014
3' UTR-dependent, miR-92-mediated restriction of Tis21 expression maintains asymmetric neural stem cell division to ensure proper neocortex size. Cell reports\| PubMed ID: 24726360	2014
Microinjection of membrane-impermeable molecules into single neural stem cells in brain tissue. Nature protocols\| PubMed ID: 24762784	2014
Neural progenitors, neurogenesis and the evolution of the neocortex. Development (Cambridge, England)\| PubMed ID: 24866113	2014
Human prominin-1 (CD133) is detected in both neoplastic and non-neoplastic salivary gland diseases and released into saliva in a ubiquitinated form. PloS one\| PubMed ID: 24911657	2014
Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division. eLife\| PubMed ID: 24996848	2014
The cell biology of neurogenesis: toward an understanding of the development and evolution of the neocortex. Annual review of cell and developmental biology\| PubMed ID: 25000993	2014
The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration. Frontiers in cellular neuroscience\| PubMed ID: 25147501	2014
An adaptive threshold in mammalian neocortical evolution. PLoS biology\| PubMed ID: 25405475	2014
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion. Science (New York, N.Y.)\| PubMed ID: 25721503	2015
Analysis of primary cilia in the developing mouse brain. Methods in cell biology\| PubMed ID: 25837388	2015
Stem cells: slow and steady wins the race. Nature neuroscience\| PubMed ID: 25919957	2015
S-phase duration is the main target of cell cycle regulation in neural progenitors of developing ferret neocortex. The Journal of comparative neurology\| PubMed ID: 25963823	2016
Neurodevelopmental LincRNA Microsyteny Conservation and Mammalian Brain Size Evolution. PloS one\| PubMed ID: 26134977	2015
Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex. PLoS biology\| PubMed ID: 26252244	2015
Lipidome of midbody released from neural stem and progenitor cells during mammalian cortical neurogenesis. Frontiers in cellular neuroscience\| PubMed ID: 26379497	2015
Novel insights into mammalian embryonic neural stem cell division: focus on microtubules. Molecular biology of the cell\| PubMed ID: 26628750	2015
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26644564	2015
Abnormal spindle-like microcephaly-associated (ASPM) mutations strongly disrupt neocortical structure but spare the hippocampus and long-term memory. Cortex; a journal devoted to the study of the nervous system and behavior\| PubMed ID: 26691732	2016
CRISPR/Cas9-induced disruption of gene expression in mouse embryonic brain and single neural stem cells in vivo. EMBO reports\| PubMed ID: 26758805	2016
Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. The EMBO journal\| PubMed ID: 26856890	2016
Comment on "Cortical folding scales universally with surface area and thickness, not number of neurons". Science (New York, N.Y.)\| PubMed ID: 26912886	2016
GEMC1 is a critical regulator of multiciliated cell differentiation. The EMBO journal\| PubMed ID: 26933123	2016
Neocortex expansion in development and evolution - from cell biology to single genes. Current opinion in neurobiology\| PubMed ID: 27258840	2016
ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. EMBO reports\| PubMed ID: 27562601	2016
Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development. eLife\| PubMed ID: 27669147	2016
Monoclonal Antibodies 13A4 and AC133 Do Not Recognize the Canine Ortholog of Mouse and Human Stem Cell Antigen Prominin-1 (CD133). PloS one\| PubMed ID: 27701459	2016
Neural progenitor cells and their role in the development and evolutionary expansion of the neocortex. Wiley interdisciplinary reviews. Developmental biology\| PubMed ID: 27865053	2017
Human-specific genomic signatures of neocortical expansion. Current opinion in neurobiology\| PubMed ID: 27912138	2017
A single splice site mutation in human-specific causes basal progenitor amplification. Science advances\| PubMed ID: 27957544	2016
A tunable refractive index matching medium for live imaging cells, tissues and model organisms. eLife\| PubMed ID: 28708059	2017
Epigenome profiling and editing of neocortical progenitor cells during development. The EMBO journal\| PubMed ID: 28765163	2017
Novel gene function and regulation in neocortex expansion. Current opinion in cell biology\| PubMed ID: 29227861	2017
Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7. Neuron\| PubMed ID: 29503187	2018
Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex. eLife\| PubMed ID: 29561261	2018
Epigenetic and Transcriptional Pre-patterning-An Emerging Theme in Cortical Neurogenesis. Frontiers in neuroscience\| PubMed ID: 29896084	2018
Brain organoids as models to study human neocortex development and evolution. Current opinion in cell biology\| PubMed ID: 30006054	2018
Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex. Neuron\| PubMed ID: 30078576	2018
A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex. Development (Cambridge, England)\| PubMed ID: 30266827	2018
Prominin-1 (CD133) modulates the architecture and dynamics of microvilli. Traffic (Copenhagen, Denmark)\| PubMed ID: 30328220	2019
Human-specific induces hallmarks of neocortical expansion in developing ferret neocortex. eLife\| PubMed ID: 30484771	2018
Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. The EMBO journal\| PubMed ID: 30523147	2019
Primate neocortex development and evolution: Conserved versus evolved folding. The Journal of comparative neurology\| PubMed ID: 30552689	2019
The centrosome protein AKNA regulates neurogenesis via microtubule organization. Nature\| PubMed ID: 30787442	2019
Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology. Cell stem cell\| PubMed ID: 30905618	2019
How the extracellular matrix shapes neural development. Open biology\| PubMed ID: 30958121	2019
Transport, Metabolism, and Function of Thyroid Hormones in the Developing Mammalian Brain. Frontiers in endocrinology\| PubMed ID: 31001205	2019
YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex. Cell reports\| PubMed ID: 31018127	2019
The Mode of Stem Cell Division Is Dependent on the Differential Interaction of β-Catenin with the Kat3 Coactivators CBP or p300. Cancers\| PubMed ID: 31324005	2019
Malformations of Human Neocortex in Development - Their Progenitor Cell Basis and Experimental Model Systems. Frontiers in cellular neuroscience\| PubMed ID: 31338027	2019
The Golgi Apparatus in Polarized Neuroepithelial Stem Cells and Their Progeny: Canonical and Noncanonical Features. Results and problems in cell differentiation\| PubMed ID: 31435803	2019
Robotic platform for microinjection into single cells in brain tissue. EMBO reports\| PubMed ID: 31469223	2019
Organoid single-cell genomic atlas uncovers human-specific features of brain development. Nature\| PubMed ID: 31619793	2019
Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis. Neuron\| PubMed ID: 31883789	2020
Genetic Modification of Brain Organoids. Frontiers in cellular neuroscience\| PubMed ID: 31920558	2019
Signs of Reduced Basal Progenitor Levels and Cortical Neurogenesis in Human Fetuses with Open Spina Bifida at 11-15 Weeks of Gestation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 31953373	2020
A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons. Translational psychiatry\| PubMed ID: 32066665	2020
Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex. eLife\| PubMed ID: 32191207	2020
Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3. The Journal of biological chemistry\| PubMed ID: 32201384	2020
Neurotransmitters as Modulators of Neural Progenitor Cell Proliferation During Mammalian Neocortex Development. Frontiers in cell and developmental biology\| PubMed ID: 32528958	2020
Human-specific increases size and folding of primate neocortex in the fetal marmoset. Science (New York, N.Y.)\| PubMed ID: 32554627	2020
Transcriptional Regulators and Human-Specific/Primate-Specific Genes in Neocortical Neurogenesis. International journal of molecular sciences\| PubMed ID: 32610533	2020
Corrigendum: Neurotransmitters as Modulators of Neural Progenitor Cell Proliferation During Mammalian Neocortex Development. Frontiers in cell and developmental biology\| PubMed ID: 32733877	2020
Basal Progenitor Morphology and Neocortex Evolution. Trends in neurosciences\| PubMed ID: 32828546	2020
Lengthening Neurogenic Period during Neocortical Development Causes a Hallmark of Neocortex Expansion. Current biology : CB\| PubMed ID: 32888487	2020
Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex. Neuron\| PubMed ID: 33080227	2020
Metabolic Regulation of Neocortical Expansion in Development and Evolution. Neuron\| PubMed ID: 33306962	2020
Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors. Cell stem cell\| PubMed ID: 19733543	2009
Sulfonated cryogel scaffolds for focal delivery in ex-vivo brain tissue cultures. Biomaterials\| PubMed ID: 33618220	2021
From stem and progenitor cells to neurons in the developing neocortex: key differences among hominids. The FEBS journal\| PubMed ID: 33638923	2022
Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility. The EMBO journal\| PubMed ID: 33938018	2021
Length of the Neurogenic Period-A Key Determinant for the Generation of Upper-Layer Neurons During Neocortex Development and Evolution. Frontiers in cell and developmental biology\| PubMed ID: 34055808	2021
Human-Specific Genes, Cortical Progenitor Cells, and Microcephaly. Cells\| PubMed ID: 34063381	2021
Neocortex expansion in development and evolution-from genes to progenitor cell biology. Current opinion in cell biology\| PubMed ID: 34098196	2021
Tissue Culture Protocols for Studying the Developing Neocortex. Bio-protocol\| PubMed ID: 34150938	2021
Generation of interspecies mouse-rat chimeric embryos by embryonic stem (ES) cell microinjection. STAR protocols\| PubMed ID: 34189467	2021
How neural stem cells contribute to neocortex development. Biochemical Society transactions\| PubMed ID: 34397081	2021
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. The EMBO journal\| PubMed ID: 34431536	2021
H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion. Science advances\| PubMed ID: 34524839	2021
Primary Cilia and Centrosomes in Neocortex Development. Frontiers in neuroscience\| PubMed ID: 34744618	2021
The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development. Frontiers in cellular neuroscience\| PubMed ID: 35140590	2021
What Are the Human-Specific Aspects of Neocortex Development? Frontiers in neuroscience\| PubMed ID: 35495057	2022
Progenitor-Based Cell Biological Aspects of Neocortex Development and Evolution. Frontiers in cell and developmental biology\| PubMed ID: 35602606	2022
Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development. Science advances\| PubMed ID: 35905187	2022
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. Science (New York, N.Y.)\| PubMed ID: 36074851	2022
Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids. EMBO reports\| PubMed ID: 36098218	2022
Human-specific ensures human-like basal progenitor levels in hominid cerebral organoids. EMBO reports\| PubMed ID: 36381990	2022
Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis. Developmental cell\| PubMed ID: 36693320	2023
Response to Comment on "Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals". Science (New York, N.Y.)\| PubMed ID: 36893240	2023