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Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification
Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification
JoVE Journal
Developmental Biology
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JoVE Journal Developmental Biology
Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification

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11:44 min

March 24, 2023

DOI:

11:44 min
March 24, 2023

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Summary

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The electroporation of primate cerebral organoids provides a precise and efficient approach to introduce transient genetic modification(s) into different progenitor types and neurons in a model system close to primate (patho)physiological neocortex development. This allows the study of neurodevelopmental and evolutionary processes and can also be applied for disease modeling.

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