Mark A. Randolph

Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School

Affiliated withMassachusetts General Hospital, Harvard Medical School Shriners Hospital for Children Massachusetts General Hospital

Research Area

Immunology and InfectionBioengineeringMedicine

Biography

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JoVE Journal Publications

ArticleTotal : 7	Year
Publication title Cited by 11	2021
Publication title Cited by 7	2022
Publication title Cited by 7	2023
Publication title Cited by 4	2024
Publication title Cited by 6	2023

Other Publications

Article	Year
Articular cartilage generation applying PEG-LA-DM/PEGDM copolymer hydrogels. BMC musculoskeletal disorders\| PubMed ID: 27255078	2016
In utero bone marrow transplantation induces kidney allograft tolerance across a full major histocompatibility complex barrier in Swine. Transplantation\| PubMed ID: 15880048	2005
Recipient bone marrow engraftment in donor tissue after long-term tolerance to a composite tissue allograft. Transplantation\| PubMed ID: 12131681	2002
Split tolerance to a composite tissue allograft in a swine model. Transplantation\| PubMed ID: 12544866	2003
Cell-based bonding of articular cartilage: An extended study. Journal of biomedical materials research. Part A\| PubMed ID: 12579566	2003
Tissue engineering of cartilage. Clinics in plastic surgery\| PubMed ID: 14621300	2003
Prolongation of skin allograft survival after neonatal injection of donor bone marrow and epidermal cells. Plastic and reconstructive surgery\| PubMed ID: 14707646	2004
Cell-based therapy for meniscal repair: a large animal study. The American journal of sports medicine\| PubMed ID: 14754738	2004
Injectable tissue-engineered cartilage with different chondrocyte sources. Plastic and reconstructive surgery\| PubMed ID: 15060348	2004
Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine. Transplantation\| PubMed ID: 15084927	2004
Composite tissue allotransplantation--a new era in plastic surgery? British journal of plastic surgery\| PubMed ID: 15191817	2004
Heterotopic limb allotransplantation model to study skin rejection in the rat. Microsurgery\| PubMed ID: 15499552	2004
Integrative repair of cartilage with articular and nonarticular chondrocytes. Tissue engineering\| PubMed ID: 15588391	2004
Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules\| PubMed ID: 15638543	2005
Tissue-engineered flexible ear-shaped cartilage. Plastic and reconstructive surgery\| PubMed ID: 15861068	2005
Producing a flexible tissue-engineered cartilage framework using expanded polytetrafluoroethylene membrane as a pseudoperichondrium. Plastic and reconstructive surgery\| PubMed ID: 16079694	2005
Long-term acceptance of renal allografts following prenatal inoculation with adult bone marrow. Transplantation\| PubMed ID: 16314799	2005
Healing potential of transplanted allogeneic chondrocytes of three different sources in lesions of the avascular zone of the meniscus: a pilot study. Archives of orthopaedic and trauma surgery\| PubMed ID: 16411123	2006
Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks. Journal of biomedical materials research. Part A\| PubMed ID: 16482551	2006
Tissue engineering cartilage with aged articular chondrocytes in vivo. Plastic and reconstructive surgery\| PubMed ID: 16816672	2006
An allogenic cell-based implant for meniscal lesions. The American journal of sports medicine\| PubMed ID: 16870819	2006
A histologic analysis of the effects of stainless steel and titanium implants adjacent to tendons: an experimental rabbit study. The Journal of hand surgery\| PubMed ID: 16945714	2006
Tissue engineered cartilage integration to live and devitalized cartilage: a study by reflectance mode confocal microscopy and standard histology. Connective tissue research\| PubMed ID: 16987750	2006
Effects of auricular chondrocyte expansion on neocartilage formation in photocrosslinked hyaluronic acid networks. Tissue engineering\| PubMed ID: 16995800	2006
Embryonic stem cell-derived motor neurons preserve muscle after peripheral nerve injury. Plastic and reconstructive surgery\| PubMed ID: 17255679	2007
Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering. Tissue engineering\| PubMed ID: 17518705	2007
Photochemical tissue bonding: a promising technique for peripheral nerve repair. The Journal of surgical research\| PubMed ID: 17543988	2007
Skin tolerance: in search of the Holy Grail. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 17903184	2008
Microvascular anastomosis using a photochemical tissue bonding technique. Lasers in surgery and medicine\| PubMed ID: 17960755	2007
Ischemic preconditioning of skeletal muscle mitigates remote injury and mortality. The Journal of surgical research\| PubMed ID: 18570927	2008
Photochemical sealing improves outcome following peripheral neurorrhaphy. The Journal of surgical research\| PubMed ID: 18599081	2009
Recipient damage after musculocutaneous transplant rejection. Transplantation\| PubMed ID: 18946349	2008
A novel murine island skin flap for ischemic preconditioning. The Journal of surgical research\| PubMed ID: 19101697	2009
Sequential limb ischemia demonstrates remote postconditioning protection of murine skeletal muscle. Plastic and reconstructive surgery\| PubMed ID: 19182659	2009
Real-time in vivo assessment of the nerve microenvironment with coherent anti-Stokes Raman scattering microscopy. Plastic and reconstructive surgery\| PubMed ID: 19182671	2009
Embryonic stem cell-derived motor neurons form neuromuscular junctions in vitro and enhance motor functional recovery in vivo. Plastic and reconstructive surgery\| PubMed ID: 19182673	2009
Engineering cartilage in a photochemically crosslinked collagen gel. The journal of knee surgery\| PubMed ID: 19216355	2009
Improving electrophysiologic and histologic outcomes by photochemically sealing amnion to the peripheral nerve repair site. Surgery\| PubMed ID: 19231584	2009
In vivo observations of cell trafficking in allotransplanted vascularized skin flaps and conventional skin grafts. Journal of plastic, reconstructive & aesthetic surgery : JPRAS\| PubMed ID: 19324598	2010
Improved survival of murine island skin flaps by prevention of reperfusion injury. Plastic and reconstructive surgery\| PubMed ID: 19407613	2009
Preparation and integration of human amnion nerve conduits using a light-activated technique. Plastic and reconstructive surgery\| PubMed ID: 19644257	2009
A high-throughput model for fat graft assessment. Lasers in surgery and medicine\| PubMed ID: 20014260	2009
Poloxamer 188 protects against ischemia-reperfusion injury in a murine hind-limb model. Plastic and reconstructive surgery\| PubMed ID: 20517088	2010
Porous poly(vinyl alcohol)-alginate gel hybrid construct for neocartilage formation using human nasoseptal cells. The Journal of surgical research\| PubMed ID: 20538292	2010
Injectable and photopolymerizable tissue-engineered auricular cartilage using poly(ethylene glycol) dimethacrylate copolymer hydrogels. Tissue engineering. Part A\| PubMed ID: 20695772	2011
Porous poly(vinyl alcohol)-hydrogel matrix-engineered biosynthetic cartilage. Tissue engineering. Part A\| PubMed ID: 20799889	2011
Survival of porcine mesenchymal stem cells over the alginate recovered cellular method. Journal of biomedical materials research. Part A\| PubMed ID: 21105156	2011
Engineering ear constructs with a composite scaffold to maintain dimensions. Tissue engineering. Part A\| PubMed ID: 21284558	2011
Polymer therapy: a novel treatment to improve fat graft viability. Plastic and reconstructive surgery\| PubMed ID: 21617461	2011
Implant-assisted meniscal repair in vivo using a chondrocyte-seeded flexible PLGA scaffold. Journal of biomedical materials research. Part A\| PubMed ID: 21800420	2011
The tissue-engineered auricle: past, present, and future. Tissue engineering. Part B, Reviews\| PubMed ID: 21827281	2012
A novel approach to adipocyte analysis. Plastic and reconstructive surgery\| PubMed ID: 22286421	2012
Properties of cartilage engineered from elderly human chondrocytes for articular surface repair. Tissue engineering. Part A\| PubMed ID: 22435677	2012
The gracilis myocutaneous free flap in swine: an advantageous preclinical model for vascularized composite allograft transplantation research. Microsurgery\| PubMed ID: 22707437	2013
The impact of liposuction cannula size on adipocyte viability. Annals of plastic surgery\| PubMed ID: 22964677	2012
Micro-mechanical fractional skin rejuvenation. Plastic and reconstructive surgery\| PubMed ID: 23357983	2013
The effect of pressure and shear on autologous fat grafting. Plastic and reconstructive surgery\| PubMed ID: 23385989	2013
Design of composite scaffolds and three-dimensional shape analysis for tissue-engineered ear. Journal of the Royal Society, Interface\| PubMed ID: 23904585	2013
Successful creation of tissue-engineered autologous auricular cartilage in an immunocompetent large animal model. Tissue engineering. Part A\| PubMed ID: 23980800	2014
Vascularized composite allograft transplant survival in miniature swine: is MHC tolerance sufficient for acceptance of epidermis? Transplantation\| PubMed ID: 24056624	2013
Prevention of capsular contracture with photochemical tissue passivation. Plastic and reconstructive surgery\| PubMed ID: 24263392	2014
Covalently tethered TGF-β1 with encapsulated chondrocytes in a PEG hydrogel system enhances extracellular matrix production. Journal of biomedical materials research. Part A\| PubMed ID: 24616326	2014
Comprehensive evaluation of peripheral nerve regeneration in the acute healing phase using tissue clearing and optical microscopy in a rodent model. PloS one\| PubMed ID: 24714405	2014
Concise review: unraveling stem cell cocultures in regenerative medicine: which cell interactions steer cartilage regeneration and how? Stem cells translational medicine\| PubMed ID: 24763684	2014
Comparative analysis of processing methods in fat grafting. Plastic and reconstructive surgery\| PubMed ID: 24945949	2014
Enhancing the stiffness of collagen hydrogels for delivery of encapsulated chondrocytes to articular lesions for cartilage regeneration. Journal of biomedical materials research. Part A\| PubMed ID: 25044419	2015
Adhesion and integration of tissue engineered cartilage to porous polyethylene for composite ear reconstruction. Journal of biomedical materials research. Part B, Applied biomaterials\| PubMed ID: 25196223	2015
Conditions for seeding and promoting neo-auricular cartilage formation in a fibrous collagen scaffold. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery\| PubMed ID: 25600627	2015
Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition. Advanced healthcare materials\| PubMed ID: 25607633	2015
Augmenting peripheral nerve regeneration using stem cells: A review of current opinion. World journal of stem cells\| PubMed ID: 25621102	2015
Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts. Transplantation\| PubMed ID: 25757218	2015
In vivo optical microscopy of peripheral nerve myelination with polarization sensitive-optical coherence tomography. Journal of biomedical optics\| PubMed ID: 25858593	2015
Abstract 104: MHC class I sharing influences the fate of the epidermal component of vascularized composite allografts in mixed chimerism based tolerance protocols in miniature Swine. Plastic and reconstructive surgery\| PubMed ID: 25942215	2014
Extensively Expanded Auricular Chondrocytes Form Neocartilage In Vivo. Cartilage\| PubMed ID: 26069703	2014
Postnatal xenogeneic B-cell tolerance in swine following in utero intraportal antigen exposure. Xenotransplantation\| PubMed ID: 26314946	2015
Light-Activated Sealing of Nerve Graft Coaptation Sites Improves Outcome following Large Gap Peripheral Nerve Injury. Plastic and reconstructive surgery\| PubMed ID: 26397251	2015
Ear-Shaped Stable Auricular Cartilage Engineered from Extensively Expanded Chondrocytes in an Immunocompetent Experimental Animal Model. Tissue engineering. Part A\| PubMed ID: 26529401	2016
Light-Activated Sealing of Acellular Nerve Allografts following Nerve Gap Injury. Journal of reconstructive microsurgery\| PubMed ID: 26878685	2016
A Biosynthetic Scaffold that Facilitates Chondrocyte-Mediated Degradation and Promotes Articular Cartilage Extracellular Matrix Deposition. Regenerative engineering and translational medicine\| PubMed ID: 26900597	2015
Improving Outcomes in Immediate and Delayed Nerve Grafting of Peripheral Nerve Gaps Using Light-Activated Sealing of Neurorrhaphy Sites with Human Amnion Wraps. Plastic and reconstructive surgery\| PubMed ID: 26910669	2016
A light-activated amnion wrap strengthens colonic anastomosis and reduces peri-anastomotic adhesions. Lasers in surgery and medicine\| PubMed ID: 26996284	2016
Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction. Journal of tissue engineering and regenerative medicine\| PubMed ID: 27256796	2017
Hyaline Articular Matrix Formed by Dynamic Self-Regenerating Cartilage and Hydrogels. Tissue engineering. Part A\| PubMed ID: 27324118	2016
Erratum: Light-Activated Sealing of Acellular Nerve Allografts following Nerve Gap Injury. Journal of reconstructive microsurgery\| PubMed ID: 27341523	2016
Photochemical Tissue Passivation Reduces Vein Graft Intimal Hyperplasia in a Swine Model of Arteriovenous Bypass Grafting. Journal of the American Heart Association\| PubMed ID: 27464790	2016
Bioengineered Self-assembled Skin as an Alternative to Skin Grafts. Plastic and reconstructive surgery. Global open\| PubMed ID: 27482479	2016
Photochemical Tissue Passivation Attenuates AV Fistula Intimal Hyperplasia. Annals of surgery\| PubMed ID: 27759615	2018
An intraluminal stent facilitates light-activated vascular anastomosis. The journal of trauma and acute care surgery\| PubMed ID: 28383474	2017
Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage. Acta biomaterialia\| PubMed ID: 29037894	2017
Wide-Field Functional Microscopy of Peripheral Nerve Injury and Regeneration. Scientific reports\| PubMed ID: 30228335	2018
Hydrazone covalent adaptable networks modulate extracellular matrix deposition for cartilage tissue engineering. Acta biomaterialia\| PubMed ID: 30419278	2019
Decellularized extracellular matrix microparticles seeded with bone marrow mesenchymal stromal cells for the treatment of full-thickness cutaneous wounds. Journal of biomaterials applications\| PubMed ID: 30651054	2019
Graft vasculopathy of vascularized composite allografts in humans: a literature review and retrospective study. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 30829423	2019
An in vitro and in vivo comparison of cartilage growth in chondrocyte-laden matrix metalloproteinase-sensitive poly(ethylene glycol) hydrogels with localized transforming growth factor β3. Acta biomaterialia\| PubMed ID: 30914256	2019
Assessment and prevention of cartilage degeneration surrounding a focal chondral defect in the porcine model. Biochemical and biophysical research communications\| PubMed ID: 31088681	2019
Photochemical Tissue Passivation Prevents Contracture of Full Thickness Wounds in Mice. Lasers in surgery and medicine\| PubMed ID: 31278757	2019
Toward Development of the Delayed Tolerance Induction Protocol for Vascularized Composite Allografts in Nonhuman Primates. Plastic and reconstructive surgery\| PubMed ID: 32221215	2020
Local Immunosuppression for Vascularized Composite Allografts: Application of Topical FK506-TyroSpheres in a Nonhuman Primate Model. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 32352521	2020
Photochemical Tissue Passivation of Arteriovenous Grafts Prevents Long-Term Development of Intimal Hyperplasia in a Swine Model. The Journal of surgical research\| PubMed ID: 32402853	2020
Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation. Biomaterials science\| PubMed ID: 32602512	2020
Cutaneous leukocyte lineages in tolerant large animal and immunosuppressed clinical vascularized composite allograft recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 32741100	2021
Mechanobiological Interactions between Dynamic Compressive Loading and Viscoelasticity on Chondrocytes in Hydrazone Covalent Adaptable Networks for Cartilage Tissue Engineering. Advanced healthcare materials\| PubMed ID: 33738966	2021
In Vivo Activity of Genetically Modified Cells Preseeded in Rat Vascularized Composite Allografts. Transplantation proceedings\| PubMed ID: 33985799	2021
Local FK506 implants in non-human primates to prevent early acute rejection in vascularized composite allografts. Annals of translational medicine\| PubMed ID: 34422982	2021
Biomimetic and mechanically supportive 3D printed scaffolds for cartilage and osteochondral tissue engineering using photopolymers and digital light processing. Biofabrication\| PubMed ID: 34479218	2021
Light-activated photosealing with human amniotic membrane strengthens bowel anastomosis in a hypotensive, trauma-relevant swine model. Lasers in surgery and medicine\| PubMed ID: 34664720	2022
Optimization of Ex Vivo Machine Perfusion and Transplantation of Vascularized Composite Allografts. The Journal of surgical research\| PubMed ID: 34670191	2022
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment. Cancer cell\| PubMed ID: 34719426	2021
A Photosealed Cap Prevents Disorganized Axonal Regeneration and Neuroma following Nerve Transection in Rats. Plastic and reconstructive surgery. Global open\| PubMed ID: 35265445	2022
Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine Mixed Chimerism. Frontiers in immunology\| PubMed ID: 35619720	2022
Exceeding the Limits of Static Cold Storage in Limb Transplantation Using Subnormothermic Machine Perfusion. Journal of reconstructive microsurgery\| PubMed ID: 35764315	2022
Acellular nipple scaffold development, characterization, and preliminary biocompatibility assessment in a swine model. Plastic and reconstructive surgery\| PubMed ID: 36472499	2022
Photo-crosslinked GelMA loaded with dental pulp stem cells and VEGF to repair critical-sized soft tissue defects in rats. Journal of stomatology, oral and maxillofacial surgery\| PubMed ID: 36584767	2022
Light-Activated Vascular Anastomosis. Surgical innovation\| PubMed ID: 35603581	2023
Bone Marrow Stem Cells with Tissue-Engineered Scaffolds for Large Bone Segmental Defects. A Systematic Review. Tissue engineering. Part B, Reviews\| PubMed ID: 36905366	2023
Continuous versus Pulsatile Flow in 24-Hour Vascularized Composite Allograft Machine Perfusion in Swine: A Pilot Study. The Journal of surgical research\| PubMed ID: 36915006	2023
Towards Optimizing Sub-Normothermic Machine Perfusion in Fasciocutaneous Flaps: A Large Animal Study. Bioengineering (Basel, Switzerland)\| PubMed ID: 38136006	2023
The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization. Bioengineering (Basel, Switzerland)\| PubMed ID: 38136031	2023
Optimized Decellularization of a Porcine Fasciocutaneaous Flap. Bioengineering (Basel, Switzerland)\| PubMed ID: 38671744	2024
Exploring Iodide and Hydrogen Sulfide as ROS Scavengers to Delay Acute Rejection in MHC-Defined Vascularized Composite Allografts. Antioxidants (Basel, Switzerland)\| PubMed ID: 38790636	2024
Machine Perfusion Enables 24-h Preservation of Vascularized Composite Allografts in a Swine Model of Allotransplantation. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 38813393	2024
VCA supercooling in a swine partial hindlimb model. Scientific reports\| PubMed ID: 38824189	2024
Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery. Biosensors & bioelectronics\| PubMed ID: 38971037	2024
[Advances and perspectives in vascularized composite allotransplantation preservation]. Bulletin de l'Academie nationale de medecine\| PubMed ID: 39906406	2024
A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction. Current issues in molecular biology\| PubMed ID: 40699674	2025