Timothy S. Blackwell

Department of Medicine, Vanderbilt University School of Medicine

Affiliated withVanderbilt University School of Medicine Vanderbilt University Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 15	2012
Publication title Cited by 14	2012
Publication title Cited by 34	2020

Other Publications

Article	Year
Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. American journal of respiratory cell and molecular biology\| PubMed ID: 16543608	2006
Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin. American journal of respiratory cell and molecular biology\| PubMed ID: 11970909	2002
Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kappaB activation in a transgenic mouse model. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract\| PubMed ID: 11992813	2002
Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12003780	2002
Modulation of endotoxin-induced NF-kappa B activation in lung and liver through TNF type 1 and IL-1 receptors. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12388356	2002
Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12517978	2003
Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12626586	2003
Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis. The Journal of surgical research\| PubMed ID: 12697416	2003
Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 12754285	2003
Endotoxin potentiates lung injury in cerulein-induced pancreatitis. American journal of surgery\| PubMed ID: 14599619	2003
Mice are resistant to the induction of a pleurodesis. Chest\| PubMed ID: 14665535	2003
Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 14672923	2004
p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14734763	2004
Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1. The Journal of biological chemistry\| PubMed ID: 14966110	2004
Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. American journal of respiratory cell and molecular biology\| PubMed ID: 15205180	2004
Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15240724	2004
CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 15516494	2005
Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation. Journal of leukocyte biology\| PubMed ID: 15563581	2005
Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. American journal of respiratory and critical care medicine\| PubMed ID: 15618458	2005
Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. American journal of respiratory and critical care medicine\| PubMed ID: 15695491	2005
Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. Journal of virology\| PubMed ID: 15919917	2005
Variability of interalveolar septal remodeling after bleomycin treatment in mice. Ultrastructural pathology\| PubMed ID: 15934165	2005
Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions. Chest\| PubMed ID: 15947325	2005
The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice. Blood\| PubMed ID: 15985536	2005
Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 16093364	2005
Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. The Journal of biological chemistry\| PubMed ID: 16100121	2005
Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. The Journal of clinical investigation\| PubMed ID: 16100570	2005
Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion. American journal of respiratory cell and molecular biology\| PubMed ID: 16210694	2006
Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. The American journal of pathology\| PubMed ID: 16251411	2005
Bioluminescence imaging. Proceedings of the American Thoracic Society\| PubMed ID: 16352761	2005
Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. The Journal of biological chemistry\| PubMed ID: 16371369	2006
Hyperoxia and apoptosis in developing mouse lung mesenchyme. Pediatric research\| PubMed ID: 16439576	2006
Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585588	2006
Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585596	2006
NIK is involved in nucleosomal regulation by enhancing histone H3 phosphorylation by IKKalpha. The Journal of biological chemistry\| PubMed ID: 16675465	2006
Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16679392	2006
Vascular endothelial growth factor levels in post-CABG pleural effusions are associated with pleural inflammation and permeability. Respiratory medicine\| PubMed ID: 16854577	2007
Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis. Pancreas\| PubMed ID: 17003648	2006
Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. Journal of leukocyte biology\| PubMed ID: 17135575	2007
Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17202330	2007
Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17220375	2007
A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis. The Journal of biological chemistry\| PubMed ID: 17261585	2007
Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. European journal of immunology\| PubMed ID: 17330822	2007
Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17475880	2007
Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17545492	2007
Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia. Virchows Archiv : an international journal of pathology\| PubMed ID: 17674038	2007
Induction and function of lipocalin prostaglandin D synthase in host immunity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17675519	2007
Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. The American journal of pathology\| PubMed ID: 17717145	2007
Tumor necrosis factor-alpha promotes malignant pleural effusion. Cancer research\| PubMed ID: 17942913	2007
Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18000061	2007
Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis. Clinical & experimental metastasis\| PubMed ID: 18008176	2008
Disease-specific gene expression profiling in multiple models of lung disease. American journal of respiratory and critical care medicine\| PubMed ID: 18029791	2008
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nature medicine\| PubMed ID: 18066075	2008
Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Molecular cancer research : MCR\| PubMed ID: 18337446	2008
Bioluminescence imaging visualizes activation of nuclear factor-kappaB in mouse cardiac transplantation. Transplantation\| PubMed ID: 18360274	2008
Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18390830	2008
Genetic determination of the role of PU.1 in macrophage gene expression. Biochemical and biophysical research communications\| PubMed ID: 18485892	2008
Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. The Journal of biological chemistry\| PubMed ID: 18490445	2008
The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer research\| PubMed ID: 18701501	2008
A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion. Journal of the National Cancer Institute\| PubMed ID: 18840818	2008
Bioluminescence: imaging modality for in vitro and in vivo gene expression. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19082962	2008
Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 19098124	2009
Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 19181746	2009
Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. The Journal of clinical investigation\| PubMed ID: 19273909	2009
Development of animal models for the acute respiratory distress syndrome. Disease models & mechanisms\| PubMed ID: 19407329	2009
Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PloS one\| PubMed ID: 19436730	2009
Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. American journal of respiratory and critical care medicine\| PubMed ID: 19556518	2009
CpG oligodeoxynucleotide triggers the liver inflammatory reaction and abrogates spontaneous tolerance. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 19642135	2009
The protein kinase IKKepsilon regulates energy balance in obese mice. Cell\| PubMed ID: 19737522	2009
Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection. Journal of cellular physiology\| PubMed ID: 19746431	2010
Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Experimental lung research\| PubMed ID: 19995280	2009
TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation. American journal of respiratory and critical care medicine\| PubMed ID: 20007931	2010
Discovery of an operon that participates in agmatine metabolism and regulates biofilm formation in Pseudomonas aeruginosa. Molecular microbiology\| PubMed ID: 20149107	2010
Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study. Molecular cancer\| PubMed ID: 20219102	2010
Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model. PloS one\| PubMed ID: 20221440	2010
NADPH oxidase limits innate immune responses in the lungs in mice. PloS one\| PubMed ID: 20300512	2010
Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest\| PubMed ID: 20371530	2010
Role of NADPH oxidase in host defense against aspergillosis. Medical mycology : official publication of the International Society for Human and Animal Mycology\| PubMed ID: 20560866	2011
Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 20562227	2010
Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. American journal of respiratory and critical care medicine\| PubMed ID: 20595227	2010
Pseudomonas aeruginosa: host defence in lung diseases. Respirology (Carlton, Vic.)\| PubMed ID: 20723140	2010
Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice. Respiratory research\| PubMed ID: 20796309	2010
NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20861353	2010
Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. The Journal of biological chemistry\| PubMed ID: 20937835	2010
Let It Be: microRNAs impact interstitial lung disease. American journal of respiratory and critical care medicine\| PubMed ID: 21193781	2011
TGFÎ² signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21441353	2011
Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine\| PubMed ID: 21512171	2011
Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. The Journal of pathology\| PubMed ID: 21557221	2011
Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free radical biology & medicine\| PubMed ID: 21605660	2011
Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction. The American journal of the medical sciences\| PubMed ID: 21613930	2011
Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21670280	2011
Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. The Journal of biological chemistry\| PubMed ID: 21757695	2011
PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21764988	2011
NF-ÎºB signaling in fetal lung macrophages disrupts airway morphogenesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21775686	2011
Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts. PloS one\| PubMed ID: 21814580	2011
NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model. Breast cancer research : BCR\| PubMed ID: 21884585	2011
NF-ÎºB inducing kinase, NIK mediates cigarette smoke/TNFÎ±-induced histone acetylation and inflammation through differential activation of IKKs. PloS one\| PubMed ID: 21887257	2011
Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections. Antimicrobial agents and chemotherapy\| PubMed ID: 21947386	2011
Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 22003088	2012
A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22048774	2011
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PloS one\| PubMed ID: 22163282	2011
Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 22180659	2012
Structure and function of OprD protein in Pseudomonas aeruginosa: from antibiotic resistance to novel therapies. International journal of medical microbiology : IJMM\| PubMed ID: 22226846	2012
Role of Endoplasmic Reticulum Stress in Age-Related Susceptibility to Lung Fibrosis. American journal of respiratory cell and molecular biology\| PubMed ID: 22227563	2012
Opposing effects of bortezomib-induced nuclear factor-ÎºB inhibition on chemical lung carcinogenesis. Carcinogenesis\| PubMed ID: 22287559	2012
Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 22287606	2012
Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell\| PubMed ID: 22304915	2012
Telomerase deficiency does not alter bleomycin-induced fibrosis in mice. Experimental lung research\| PubMed ID: 22394286	2012
Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Experimental lung research\| PubMed ID: 22394287	2012
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22415303	2012
Regulation of innate immunity by NADPH oxidase. Free radical biology & medicine\| PubMed ID: 22583699	2012
MicroRNA-181b regulates NF-ÎºB-mediated vascular inflammation. The Journal of clinical investigation\| PubMed ID: 22622040	2012
Cooperation Between Classical and Alternative NF-ÎºB Pathways Regulates Pro-Inflammatory Responses in Epithelial Cells. American journal of respiratory cell and molecular biology\| PubMed ID: 22652196	2012
The Alveolar Epithelium Determines Susceptibility to Lung Fibrosis in Hermansky-Pudlak Syndrome. American journal of respiratory and critical care medicine\| PubMed ID: 23043085	2012