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Targeted Microinjection and Electroporation of Primate Cerebral Organoids for Genetic Modification (Video) | JoVE
Generation of Cerebral Organoids from Primate-Induced Pluripotent Stem Cells (IPSCs) (Video) | JoVE
Electroporation of Primate Cerebral Organoids (Video) | JoVE
灵长类大脑类器官的电穿孔提供了一种精确有效的方法,将瞬时遗传修饰引入接近灵长类(病理)生理新皮层发育的模型系统中的不同祖细胞类型和神经元中。这允许研究神经发育和进化过程,也可以应用于疾病建模。
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