Aged Rodent Model
Aged Rodent Model - Related Videos
06:58
Frailty Assessment in an Aging Mouse Model
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2025
The goal of the present protocol is to provide instructions and guidelines for assessing physical frailty in C57Bl/6x129J laboratory mice. Specific details regarding each measure used in the physical frailty index are explained. Several methods for reporting frailty results are also presented.
10:29
Principles of Rodent Surgery for the New Surgeon
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Cited by 56 •
2011
Before attempting surgery, a new surgeon should have training in basic surgical techniques and concepts. This article will present basic surgical considerations with an emphasis on rodents.
12:59
Barnes Maze Testing Strategies with Small and Large Rodent Models
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Cited by 171 •
2014
The dry-land Barnes maze is widely used to measure spatial navigation ability in response to mildly aversive stimuli. Over consecutive days, performance (e.g. latency to locate escape cage) of control subjects improves, indicative of normal learning and memory. Differences between rats and mice necessitate apparatus and methodology changes that are detailed here.
09:40
Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
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Cited by 35 •
2016
Pulmonary arterial hypertension (PAH) is a disease of pulmonary arterioles that leads to their obliteration and the development of right ventricular failure. Rodent models of PAH are critical in understanding the pathophysiology of PAH. Here we demonstrate hemodynamic characterization, with right heart catheterization and echocardiography, in the mouse and rat.
07:58
Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
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Cited by 14 •
2011
Partially isolated cortex (“undercut”) is an efficient animal model of posttraumatic epileptogenesis. Here we demonstrate how to make a novel surgical device and use it to make more precise and consistent lesions to generate this model.
FAQs
Behavioral performance in later life may reflect changes in several systems at once. Altered neural circuits can affect learning or memory, while sensory or motor decline can reduce task performance even when cognition is not the primary limitation. Researchers therefore interpret behavioral scores alongside relevant controls and conditions rather than attributing every age-related difference to a single neural mechanism.
Age-related behavioral changes can resemble effects caused by disease, injury, or experimental treatment. Comparing appropriately selected aged and young adult animals under controlled conditions helps identify changes associated with aging itself. This distinction improves interpretation by indicating whether an observed difference reflects a general aging process or an additional pathological or experimental influence.
Strain, sex, housing, health status, and testing conditions can all shape behavioral outcomes. Differences in these factors may alter locomotion, social interaction, sleep, or performance in learning tasks independently of chronological age. Keeping them controlled, documented, and comparable across groups strengthens reproducibility and makes age-related effects easier to interpret.
A typical comparison places aged animals and young adults in the same behavioral framework, using matched testing conditions and clearly defined outcomes. Researchers then examine differences across tasks relevant to learning, memory, anxiety, social interaction, locomotion, or sleep. Consistent procedures help separate age-associated patterns from variation caused by the experimental environment.
These models support assessment of multiple behavioral domains, including learning, memory, anxiety, social interaction, locomotion, and sleep. Examining several domains can reveal whether aging affects a specific function or produces broader changes across behavior. Such profiles also help researchers relate behavioral outcomes to altered neural circuits, sensory and motor function, inflammation, or homeostasis.
It is useful when a study needs to examine how later-life biological changes influence behavior or to distinguish normal age-related change from disease, injury, or treatment effects. Controlled comparisons can provide a behavioral baseline for aging research and help evaluate whether an experimental condition is associated with additional impairment, preservation, or change across relevant tasks.