Mobile Fnirs

Mobile fNIRS (functional near-infrared spectroscopy) is a wearable neuroimaging method that measures changes in brain oxygenation during behavior outside a stationary laboratory setup. Light-emitting optodes send near-infrared light through the scalp, and detectors estimate changes in oxyhemoglobin and deoxyhemoglobin concentrations from the light that returns, providing an indirect measure of cortical activity. Because the system can be used during movement and naturalistic tasks, mobile fNIRS supports research on attention, decision-making, motor behavior, and social interaction. It helps link brain activity with real-world behavior while complementing laboratory neuroimaging methods.

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Education

JoVE Science Education - Chemistry

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2023

The electrophoretic mobility shift assay (EMSA) is a biochemical procedure used to elucidate binding between proteins and nucleic acids. In this assay a radiolabeled nucleic acid and test protein are mixed. Binding is determined via gel electrophoresis which separates components based on mass, charge, and conformation. This video shows the concepts of EMSA and a general procedure, including gel and protein preparation, binding, electrophoresis, and detection. Applications covered in this video...

Mobile Marketing

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2024

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Research

JoVE Journal - Chemistry

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Cited by 2 •

2022

Ion mobility spectrometry (IMS) is an interesting complement to mass spectrometry for the characterization of biomolecules, notably because it is sensitive to isomerism. This protocol describes a tandem IMS (IMS/IMS) experiment, which allows the isolation of a molecule and the generation of the mobility profiles of its fragments.

Research

JoVE Journal - Behavior
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fMRI Validation of fNIRS Measurements During a Naturalistic Task

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Cited by 107 •

2015

We present a method to compare functional brain activity recorded during a naturalistic task using fNIRS with activity recorded during fMRI.

Research

JoVE Journal - Biology
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Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

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Cited by 26 •

2014

The here described fluorescence-based calcium mobilization assay is a medium-throughput reverse pharmacology screening system for the identification of functionally activating ligand(s) of orphan G protein-coupled receptors (GPCRs).

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