Immunodeficient Nude Rats
Immunodeficient Nude Rats - Related Videos
07:12
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Cited by 1 •
2017
The goal of this protocol is to generate a nude rat osteoporosis-related vertebral compression fracture model that can be longitudinally evaluated in vivo using a semiautomated microcomputed tomography-based quantitative structural analysis.
06:55
Bioengineering Human Microvascular Networks in Immunodeficient Mice
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Cited by 21 •
2011
Here, we describe a methodology to deliver human cord blood-derived endothelial colony-forming cells (ECFCs) and bone marrow-derived mesenchymal stem cells (MSCs), embedded in a collagen/fibronectin gel, subcutaneously into immunodeficient mice. This cell/gel combination generates a human vascular network that connects with the mouse vasculature.
12:23
Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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Cited by 16 •
2012
In the pathogenesis of bone metastasis, angiogenesis is a crucial process and therefore represents a target for imaging and therapy. Here, we present a rat model of site-specific breast cancer bone metastasis and describe strategies to non-invasively image angiogenesis in vivo using magnetic resonance imaging, volumetric computed tomography and ultrasound.
01:25
Immunodeficiency Diseases
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2024
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications. There are three main causes of immunodeficiency disorders...
08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
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Cited by 11 •
2015
Although Candida infection models are available to study host immune resistance, a model to study T cell mediated immunopathology in the context of Candida infection is absent. Here we describe a method to establish Th17 immunopathology associated with oral Candida infection in immunodeficient mice.
FAQs
Congenital thymic deficiency limits the development of T cells. This weakened adaptive immune response reduces rejection of transplanted cells, tissues, and engineered biomaterials. Because the model retains other biological systems for evaluation, investigators can examine how a construct behaves in a living organism rather than relying only on isolated laboratory tests.
The reduced rejection response creates a practical window for evaluating implanted materials and living grafts. Investigators can focus on whether a construct remains present, integrates with surrounding tissue, supports vascularization, or contributes to functional recovery, while the model's preserved biological systems still provide living context. This helps separate design and performance questions from immediate graft rejection.
The rat's size accommodates surgical implantation and repeated monitoring over time. This allows researchers to follow changes in tissue integration, vascularization, biocompatibility, and functional recovery during longitudinal studies. Such observations provide information about how an engineered construct performs under living conditions and help identify promising designs for further investigation.
Researchers can examine vascularization, integration with surrounding tissues, biocompatibility, and functional recovery after implantation. These outcomes show whether a tissue-engineered construct or device remains compatible with the host environment and performs its intended role over time. The model therefore supports assessment of both biological responses and the practical behavior of implanted systems.
These rats support studies of tissue-engineered constructs, implanted devices, stem-cell therapies, and tumor models. Their reduced graft rejection is particularly useful when investigators need to observe transplanted cells or tissues in vivo. The same experimental setting can also reveal how an engineered material interacts with living tissue during implantation and follow-up.
Results from these studies can help investigators determine whether a tissue-engineered construct, implanted device, or cell-based therapy merits additional development. Evidence of vascularization, integration, biocompatibility, or functional recovery may support progression toward larger animal studies or clinical research. The model thus provides an intermediate living test environment between initial design work and later-stage evaluation.